Title:
METHOD FOR PRODUCING AMIDE
Document Type and Number:
WIPO Patent Application WO/2020/137545
Kind Code:
A1
Abstract:
A method for producing an amide, wherein after causing a dehydration condensation of carboxylic acids or a reaction between a carboxylic acid and a halogenated formic acid ester, a first base is reacted therewith and an amine is reacted therewith, thereby obtaining an amide, with the reaction with a first base and/or the reaction with an amine being carried out by addition of an acid.
Inventors:
FUSE SHINICHIRO (JP)
OTAKE YUMA (JP)
NAKAMURA HIROYUKI (JP)
OTAKE YUMA (JP)
NAKAMURA HIROYUKI (JP)
Application Number:
PCT/JP2019/048458
Publication Date:
July 02, 2020
Filing Date:
December 11, 2019
Export Citation:
Assignee:
TOKYO INST TECH (JP)
YOKOGAWA ELECTRIC CORP (JP)
YOKOGAWA ELECTRIC CORP (JP)
International Classes:
C07B53/00; C07C269/06; C07C271/22; C07K1/02; C07K1/10
Foreign References:
| JPS62149699A | 1987-07-03 | |||
| JPH08504779A | 1996-05-21 | |||
| JP2006502128A | 2006-01-19 | |||
| JPH0262892A | 1990-03-02 | |||
| JP2018241598A | 2018-12-25 |
Other References:
SHINICHIRO FUSE , YUTO MIFUNE , HIROYUKI NAKAMURA , HIROSHI TANAKA: "Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation", NATURE COMMUNICATIONS, vol. 7, 13491, 28 November 2016 (2016-11-28), pages 1 - 7, XP055662919, DOI: 10.1038/ncomms13491
FUSE, S.MIFUNE, Y.TAKAHASHI, T.: "Efficient Amide Bond Formation through a Rapid and Strong Activation of Carboxylic Acids in a Microflow Reactor", ANGEW CHEM., vol. 53, 2014, pages 851 - 855, XP055580806, DOI: 10.1002/anie.201307987
FUSE, S.MIFUNE, Y.NAKAMURA, H.TANAKA, H.: "Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation", NAT. COMMUN., vol. 7, 2016, pages 13491
YUMA OTAKEHIROYUKI NAKAMURASHINICHIRO FUSE: "An Efficient Synthesis of N-Methylated Peptides Using Micro-Flow Technology", THE 97TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN, 16 March 2017 (2017-03-16), pages 3F4 - 14
See also references of EP 3904317A4
FUSE, S.MIFUNE, Y.TAKAHASHI, T.: "Efficient Amide Bond Formation through a Rapid and Strong Activation of Carboxylic Acids in a Microflow Reactor", ANGEW CHEM., vol. 53, 2014, pages 851 - 855, XP055580806, DOI: 10.1002/anie.201307987
FUSE, S.MIFUNE, Y.NAKAMURA, H.TANAKA, H.: "Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation", NAT. COMMUN., vol. 7, 2016, pages 13491
YUMA OTAKEHIROYUKI NAKAMURASHINICHIRO FUSE: "An Efficient Synthesis of N-Methylated Peptides Using Micro-Flow Technology", THE 97TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN, 16 March 2017 (2017-03-16), pages 3F4 - 14
See also references of EP 3904317A4
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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