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Title:
METHOD FOR PRODUCING AMINO ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2020/059891
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for producing (2S,5R)-5-(protected oxyamino)piperidine-2-carboxylic acid derivatives, wherein the method can be carried out under mild reaction conditions eliminating the need for cryogenic facilities, is safer, supports easy control of the target material quality, has a good operability at the site of production, and requires less cost. A method for producing a compound with general formula (2): wherein, PG1 represents a protective group for an amino group, R represents a C1-8 hydrocarbon group optionally having a substituent, PG2 represents a protective group for an amino group and PG3 represents a protective group for a hydroxyl group, the method being characterized by comprising a step of reacting, in a solvent in the presence of a base, a compound represented by general formula (1): wherein LG represents a leaving group, and the remaining symbols are as defined above, with a hydroxylamine derivative represented by the general formula PG2NHOPG3, wherein the symbols are as defined above.

Inventors:
MURAI MASATO (JP)
TAKEHARA JUN (JP)
OKADO DAIKI (JP)
Application Number:
PCT/JP2019/037399
Publication Date:
March 26, 2020
Filing Date:
September 24, 2019
Export Citation:
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Assignee:
API CORP (JP)
International Classes:
C07D211/60
Domestic Patent References:
WO2017167218A12017-10-05
WO2009091856A22009-07-23
WO2010126820A22010-11-04
WO2014200786A12014-12-18
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WO2013180197A12013-12-05
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WO2014200786A12014-12-18
Foreign References:
US20140275001A12014-09-18
CN105061425A2015-11-18
US9120795B22015-09-01
Other References:
MANGION, I. K. ET AL.: "A concise synthesis of a beta -lactamase inhibitor", ORGANIC LETTERS, vol. 13, no. 20, 2011, pages 5480 - 5483, XP002762914, ISSN: 1523-7052, DOI: 10.1021/ol202195n
SULSKY, R. ET AL.: "Alkylation of N-benzyloxyureas and carbamates", TETRAHEDRON LETTERS, vol. 30, no. 1, 1989, pages 31 - 34, XP055693409, ISSN: 0040-4039
CHEM. REV., vol. 91, 1991, pages 165 - 195
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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