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Title:
METHOD FOR PRODUCING AMINOGLYCOSIDE ANTIBIOTIC SUBSTANCE EFFECTIVE FOR MULTIDRUG-RESISTANT BACTERIA
Document Type and Number:
WIPO Patent Application WO/2019/230863
Kind Code:
A1
Abstract:
Disclosed are: a method for manufacturing a compound (5-epi-4"-N-(L-isoceryl)apramycin) and 5-epiapramycin; and an intermediate used for said method. The method of the present invention is useful in that the compound (5-epi-4"-N-(L-isoceryl)apramycin) can be efficiently and completely produced.

Inventors:
IMAI TAKAHIRO (JP)
MURA HIROAKI (JP)
MORI SHINSUKE (JP)
UMEMURA EIJIRO (JP)
OTSUKA YASUNARI (JP)
TAKAHASHI YOSHIAKI (JP)
Application Number:
PCT/JP2019/021456
Publication Date:
December 05, 2019
Filing Date:
May 30, 2019
Export Citation:
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Assignee:
MEIJI SEIKA PHARMA CO LTD (JP)
MICROBIAL CHEM RES FOUND (JP)
International Classes:
C07H15/224; A61K31/7036; A61P31/04
Domestic Patent References:
WO2017018528A12017-02-02
WO2018139599A12018-08-02
Foreign References:
JPS5772999A1982-05-07
JPS5772998A1982-05-07
JP2013537177A2013-09-30
US4360665A1982-11-23
US4379917A1983-04-12
Other References:
O'CONNOR SEAN ET AL.: "Apramycin, a unique aminocyclitol antibiotic", JOURNAL OF ORGANIC CHEMISTRY, vol. 41, no. 12, 1976, pages 2087 - 2092, XP055662377
ABE YOSHIO ET AL.: "Aminoglycoside antibiotics. XIV. Synth esis and activity of 6-0-(3-amino-3-deoxy- alpha-D-glucopyranosy 1)- and 5-O-(beta -D-ribofuranosyl)apramycins", THE JOURNAL OF ANTIBIOTICS, vol. 34, no. 11, 1981, pages 1434 - 1446
ENEVA G. I. ET AL.: "Complete 'H and 13C NMR Assignments for Apramycin, Sisomicin and Some N-and N,O-Polyacetylated Aminoglycosides", MAGNETIC RESONANCE IN CHEMISTRY, vol. 30, no. 9, 1992, pages 841 - 846, XP055662379
FENNER AMANDA M. ET AL.: "Synthesis, separation, and characterization of amphiphilic sulfated oligosaccharides enabled by reversed-phase ion pairing LC and LC-MS methods", CARBOHYDRATE RESEARCH, vol. 346, no. 17, 2011, pages 2792 - 2800, XP028115459
FENNER AMANDA M. ET AL.: "Selective Inhibition of Bacterial and Human Topoisomerases by N-Arylacyl 0-Sulfonated Aminogly coside Derivatives", ACS MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 5, 2013, pages 470 - 474, XP055662380
Attorney, Agent or Firm:
NAGAI Hiroshi et al. (JP)
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