Title:
METHOD FOR PRODUCING DIAMINOBENZOIC ACID ESTER
Document Type and Number:
WIPO Patent Application WO/2019/235493
Kind Code:
A1
Abstract:
The present invention provides a method by which a diaminobenzoic acid ester and a benzimidazole derivative are able to be produced more easily with use of lower cost materials. The present invention includes a method for producing a diaminobenzoic acid ester represented by formula (3), wherein an anthranilic acid ester represented by formula (1) and an azidizing agent are brought into contact with each other in the presence of an oxidant and a copper compound, thereby producing an azide form of an anthranilic acid ester, which is represented by formula (2), and the thus-obtained azide form of an anthranilic acid ester is subsequently reduced. (In the formulae, R1 represents an alkyl group having 1-6 carbon atoms, an alkoxyalkyl group having 2-12 carbon atoms, an aralkyl group having 7-10 carbon atoms or an alkoxyaralkyl group having 8-11 carbon atoms.)
Inventors:
SEKI MASAHIKO (JP)
Application Number:
PCT/JP2019/022230
Publication Date:
December 12, 2019
Filing Date:
June 04, 2019
Export Citation:
Assignee:
TOKUYAMA CORP (JP)
International Classes:
C07C227/16; C07C229/60; C07C247/18; C07D235/26; C07B61/00
Domestic Patent References:
| WO2008012852A1 | 2008-01-31 |
Other References:
YOSHIDA, SUGURU ET AL.: "Formal C-H-Azidation-Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2014, no. 19, July 2014 (2014-07-01), pages 3991 - 3995, XP055663083
SRINIVASA, G. R. ET AL.: "Zinc/ammonium formate: a chemoselective and cost-effective protocol for the reduction of azides to amines", JOURNAL OF CHEMICAL RESEARCH (S, vol. 10, 2003, pages 630 - 631
SRINIVASA, G. R. ET AL.: "Zinc/ammonium formate: a chemoselective and cost-effective protocol for the reduction of azides to amines", JOURNAL OF CHEMICAL RESEARCH (S, vol. 10, 2003, pages 630 - 631
Attorney, Agent or Firm:
SSINPAT PATENT FIRM (JP)
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