Title:
METHOD FOR PRODUCING DIPHENYLMETHANE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2017/217792
Kind Code:
A1
Abstract:
The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.
Inventors:
YOON HEE-KYOON (KR)
PARK SE-HWAN (KR)
YOON JI-SUNG (KR)
CHOI SOONGYU (KR)
SEO HEE JEONG (KR)
PARK EUN-JUNG (KR)
KONG YOUNGGYU (KR)
SONG KWANG-SEOP (KR)
KIM MIN JU (KR)
PARK SO OK (KR)
PARK SE-HWAN (KR)
YOON JI-SUNG (KR)
CHOI SOONGYU (KR)
SEO HEE JEONG (KR)
PARK EUN-JUNG (KR)
KONG YOUNGGYU (KR)
SONG KWANG-SEOP (KR)
KIM MIN JU (KR)
PARK SO OK (KR)
Application Number:
PCT/KR2017/006271
Publication Date:
December 21, 2017
Filing Date:
June 15, 2017
Export Citation:
Assignee:
DAE WOONG PHARMA (KR)
GREEN CROSS CORP (KR)
GREEN CROSS CORP (KR)
International Classes:
C07D407/04; C07D307/78; C07D409/04
Domestic Patent References:
| WO2012041898A1 | 2012-04-05 | |||
| WO2015124877A1 | 2015-08-27 |
Foreign References:
| KR20140022086A | 2014-02-21 | |||
| KR20140114304A | 2014-09-26 |
Other References:
KANG, S. Y. ET AL.: "Glucosides with Cyclic Diarylpolynoid as Novel C-aryl Glucoside SGL.T2 Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 12, 2011, pages 3759 - 3763, XP028387842
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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