Title:
METHOD FOR PRODUCING GLYCOSIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/070507
Kind Code:
A1
Abstract:
A purpose of the present invention is to provide a method for producing a high-purity glycoside compound. The present invention provides a method for producing a glycoside compound of formula (3) (in the formula, Ba, i-Pr, and n are as defined below) by reacting a glycoside compound of formula (1) (in the formula, Ba represents an adenine group optionally substituted by an acyl group and i-Pr represents an isopropyl group.) and an ether compound of formula (2) (in the formula, R1 represents a C1-C6 alkyl group or a phenyl group, and n represents 0 or 1.) in at least one solvent selected from the group consisting of tetrahydropyran and 4-methyltetrahydropyran in the presence of one or more halogenating agents selected from the group consisting of halogens, N-halogenated succinimides, and N-halogenated hydantoins.
Inventors:
SAITO TATSUYA (JP)
IHARA HIDEKI (JP)
IHARA HIDEKI (JP)
Application Number:
PCT/JP2020/032609
Publication Date:
April 15, 2021
Filing Date:
August 28, 2020
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
C07H23/00
Domestic Patent References:
| WO2016159374A1 | 2016-10-06 | |||
| WO2013027843A1 | 2013-02-28 | |||
| WO2008016079A1 | 2008-02-07 | |||
| WO2019208571A1 | 2019-10-31 | |||
| WO2016159374A1 | 2016-10-06 |
Foreign References:
| JP2019185109A | 2019-10-24 | |||
| JP5168145B2 | 2013-03-21 | |||
| JP2016050203A | 2016-04-11 |
Other References:
Y. SHIBA, H. MASUDA, N. WATANABE, T. EGO, K. TAKAGAKI, K. ISHIYAMA, T. OHGI, J. YANO: "Chemical synthesis of a very long oligoribonucleotide with 2-cyanoethoxymethyl (CEM) as the 2'-O-protecting group: structural identification and biological activity of a synthetic 110mer precursor-microRNA candidate", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD., vol. 35, no. 10, 22 April 2007 (2007-04-22), pages 3287 - 3296, XP055127336, ISSN: 03051048, DOI: 10.1093/nar/gkm202
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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