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Patent Searching and Data


Title:
METHOD FOR PRODUCING INTERMEDIATE USEFUL FOR SYNETHESIS OF SGLT INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2020/036382
Kind Code:
A1
Abstract:
The present invention relates to a method for producing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as a SGLT inhibitor. A method for synthesizing a compound of formula 7 according to the present invention has solved the problem of an existing synthesis process which requires an additional process due to the synthesis of Grignard reagent and the management of a related substance. In addition, the process can be simplified by minimizing the formation of the related substance and eliminating the need for reprocessing of reaction products, thereby becoming capable of maximizing a yield of a diphenylmethane derivative.

Inventors:
LI QING RI (KR)
YOON HEE KYOON (KR)
Application Number:
PCT/KR2019/010123
Publication Date:
February 20, 2020
Filing Date:
August 09, 2019
Export Citation:
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Assignee:
DAE WOONG PHARMA (KR)
International Classes:
C07D307/82; C07D409/04; C07H1/00; C07H7/06
Domestic Patent References:
WO2009014970A12009-01-29
Foreign References:
KR20140022086A2014-02-21
KR20170142904A2017-12-28
KR101770302B12017-08-22
KR20170142904A2017-12-28
Other References:
XU, G. ET AL.: "Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, 2014, pages 1236 - 1251, XP055119035, DOI: 10.1021/jm401780b
GUO, C. ET AL.: "The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, 2014, pages 3414 - 3422, XP009508986
See also references of EP 3838894A4
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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