Title:
METHOD FOR PRODUCING MATURE CHONDROCYTES AND MATURE CHONDROCYTE-CONTAINING COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/158152
Kind Code:
A1
Abstract:
[Problem] To provide a method for producing mature chondrocytes suitable for transplantation. [Solution] A method for producing mature chondrocytes, said method comprising a cartilage culture step for culturing a cartilage using a first culture medium to give mature chondrocytes, wherein the first culture medium contains drocortisone and FGF-2.
Inventors:
YANAGA HIROKO (JP)
YANAGA KATSU (JP)
YANAGA KATSU (JP)
Application Number:
PCT/JP2021/045015
Publication Date:
July 28, 2022
Filing Date:
December 07, 2021
Export Citation:
Assignee:
REGENESIS SCIENCE CO LTD (JP)
International Classes:
C12N5/077
Domestic Patent References:
| WO2016076102A1 | 2016-05-19 | |||
| WO2002012451A1 | 2002-02-14 | |||
| WO2005105992A1 | 2005-11-10 | |||
| WO1998059035A2 | 1998-12-30 |
Foreign References:
| JP2006314759A | 2006-11-24 | |||
| JP2005000143A | 2005-01-06 | |||
| JP2000515023A | 2000-11-14 | |||
| CN104630138A | 2015-05-20 | |||
| JP2013018756A | 2013-01-31 | |||
| JP5139294B2 | 2013-02-06 | |||
| JP5526320B2 | 2014-06-18 |
Other References:
VACANTI CA, LANGER R, SCHLOO B, VACANTI JP: "Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation", PLAST RECONSTR SURG, vol. 88, 1991, pages 753 - 759
CAO YVACANTI JPPAIGE KTUPTON JVACANTI CA: "Transplantation of Chondrocytes Utilizing a Polymer-Cell Construct to Produce Tissue-Engineered Cartilage in the Shape of a Human Ear", PLAST RECONSTR SURG, vol. 100, 1997, pages 297 - 302, XP008126393, DOI: 10.1097/00006534-199708000-00001
SANTAVIRTA SKONTTINEN YTSAITO T ET AL.: "Immune response to polyglycolic acid implants", J BONE JOINT SURG BR, vol. 72, 1990, pages 597 - 600, XP000901089
NEIDEL JZEIDLER U: "Independent effects of interleukin 1 on proteoglycan synthesis and proteoglycan breakdown of bovine articular cartilage in vitro", AGENTS ACTIONS, vol. 39, 1993, pages 82 - 90
VACANTI CA: "The history of tissue engineering", J CELL MOL MED, vol. 10, 2006, pages 569 - 576
YANAGA H.IMAI K.KOGA M.YANAGA K: "Cell-engineered human elastic chondrocytes regenerate natural scaffold in vitro and neocartilage with neo-perichondrium in the human body post-transplantation", TISSUE ENG. PART A., vol. 18, 2012, pages 2020 - 2029
YANAGA H.IMAI K.FUJIMOTO T.YANAGA K: "Generating ears from cultured autologous auricular chondrocytes by using two-stage implantation in treatment of microtia", PLAST RECONSTR SURG, vol. 124, 2009, pages 817 - 825
MIKULA-PIETRASIK JKUCZMARSKA AKUCIN'SKA MMURIASET M: "Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8/CXCL8", ANGIOGENESIS, vol. 15, 2012, pages 361 - 376, XP035092983, DOI: 10.1007/s10456-012-9266-0
NIU JAZFER AZHELYABOVSKA OFATMA SKOLATTUKUDY PE: "Monocyte Chemotactic Protein (MCP)-1 Promotes Angiogenesis via a Novel Transcription Factor, MCP-1-induced Protein (MCPIP", J BIOL CHEM, vol. 283, no. 21, 23 May 2008 (2008-05-23), pages 14542 - 5, XP055116978, DOI: 10.1074/jbc.M802139200
HONG KHRYU JHAN KH: "Monocyte Chemoattractant protein-1-induced Angiogenesis Is Mediated by Vascular Endothelial Growth factor-A", BLOOD, vol. 105, 2005, pages 1405 - 1407
CAO YVACANTI JPPAIGE KTUPTON JVACANTI CA: "Transplantation of Chondrocytes Utilizing a Polymer-Cell Construct to Produce Tissue-Engineered Cartilage in the Shape of a Human Ear", PLAST RECONSTR SURG, vol. 100, 1997, pages 297 - 302, XP008126393, DOI: 10.1097/00006534-199708000-00001
SANTAVIRTA SKONTTINEN YTSAITO T ET AL.: "Immune response to polyglycolic acid implants", J BONE JOINT SURG BR, vol. 72, 1990, pages 597 - 600, XP000901089
NEIDEL JZEIDLER U: "Independent effects of interleukin 1 on proteoglycan synthesis and proteoglycan breakdown of bovine articular cartilage in vitro", AGENTS ACTIONS, vol. 39, 1993, pages 82 - 90
VACANTI CA: "The history of tissue engineering", J CELL MOL MED, vol. 10, 2006, pages 569 - 576
YANAGA H.IMAI K.KOGA M.YANAGA K: "Cell-engineered human elastic chondrocytes regenerate natural scaffold in vitro and neocartilage with neo-perichondrium in the human body post-transplantation", TISSUE ENG. PART A., vol. 18, 2012, pages 2020 - 2029
YANAGA H.IMAI K.FUJIMOTO T.YANAGA K: "Generating ears from cultured autologous auricular chondrocytes by using two-stage implantation in treatment of microtia", PLAST RECONSTR SURG, vol. 124, 2009, pages 817 - 825
MIKULA-PIETRASIK JKUCZMARSKA AKUCIN'SKA MMURIASET M: "Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8/CXCL8", ANGIOGENESIS, vol. 15, 2012, pages 361 - 376, XP035092983, DOI: 10.1007/s10456-012-9266-0
NIU JAZFER AZHELYABOVSKA OFATMA SKOLATTUKUDY PE: "Monocyte Chemotactic Protein (MCP)-1 Promotes Angiogenesis via a Novel Transcription Factor, MCP-1-induced Protein (MCPIP", J BIOL CHEM, vol. 283, no. 21, 23 May 2008 (2008-05-23), pages 14542 - 5, XP055116978, DOI: 10.1074/jbc.M802139200
HONG KHRYU JHAN KH: "Monocyte Chemoattractant protein-1-induced Angiogenesis Is Mediated by Vascular Endothelial Growth factor-A", BLOOD, vol. 105, 2005, pages 1405 - 1407
Attorney, Agent or Firm:
HIROSE Takayuki (JP)
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