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Title:
METHOD FOR PRODUCING PEPTIDE COMPOUND CONTAINING N-SUBSTITUTED-AMINO ACID RESIDUE
Document Type and Number:
WIPO Patent Application WO/2022/138891
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for producing a high-purity peptide compound with high efficiency and high yield. It is found that the problem can be solved by supporting a peptide on a resin for solid-phase synthesis use prior to a first extension reaction in a solid-phase method.

Inventors:
MORITA YUYA (JP)
NOMURA KENICHI (JP)
Application Number:
PCT/JP2021/048093
Publication Date:
June 30, 2022
Filing Date:
December 24, 2021
Export Citation:
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Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K1/04; C07C269/06; C07C271/22; C07K5/06; C07K5/08; C07K5/10; C07K7/06; C07K7/64
Domestic Patent References:
WO2018225851A12018-12-13
WO2013100132A12013-07-04
WO2018115864A12018-06-28
WO2020122182A12020-06-18
WO2018225864A12018-12-13
WO2018225851A12018-12-13
Foreign References:
JP2007332042A2007-12-27
JP2010529957A2010-09-02
JP2006513980A2006-04-27
JP2014162722A2014-09-08
Other References:
FUTURE MED. CHEM., vol. 1, 2009, pages 1289 - 1310
ACC. CHEM. RES., vol. 41, 2008, pages 1331 - 1342
ANGEW. CHEM. INT. ED., vol. 52, 2013, pages 254 - 269
CHEM. REV., vol. 119, 2019, pages 10360 - 10391
J. PEPTIDE RES., vol. 65, 2005, pages 153 - 166
AMINO ACIDS, PEPTIDES AND PROTEINS IN ORGANIC CHEMISTRY: BUILDING BLOCKS, CATALYSIS AND COUPLING CHEMISTRY, vol. 3, 2011
AMINO ACIDS, vol. 50, 2018, pages 39 - 68
SOLID PHASE PEPTIDE SYNTHESIS, 6 November 2020 (2020-11-06)
QSAR COMB. SCI., vol. 26, 2007, pages 1027 - 1035
BIOPOLYMERS, vol. 98, 2012, pages 89 - 97
ACS COMB. SCI., vol. 15, 2013, pages 229 - 234
MERCK: "Solid Phase Synthesis Handbook", 1 May 2002
Attorney, Agent or Firm:
HASEGAWA, Yoshiki et al. (JP)
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