Title:
METHOD FOR PRODUCING PEPTIDE, REAGENT FOR FORMING PROTECTIVE GROUP, AND FUSED POLYCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/138605
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for efficiently producing a peptide having a high purity, a reagent for forming a protective group having excellent deprotection properties, and a novel fused polycyclic compound. According to the present invention, provided are: a method for producing a peptide, said method comprising a step for using a polycyclic compound represented by formula (1); a reagent for forming a protective group, said reagent containing the polycyclic compound; and the polycyclic compound. At least one of R1 to R8 and R110 has RA, wherein RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group and at least one of the aliphatic hydrocarbon groups has 3 or more carbon atoms.
Inventors:
TSUYAMA HIROAKI (JP)
Application Number:
PCT/JP2021/047183
Publication Date:
June 30, 2022
Filing Date:
December 21, 2021
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C07K1/06; C07C269/06; C07C271/22; C07D311/88
Domestic Patent References:
| WO2018021233A1 | 2018-02-01 | |||
| WO2019184089A1 | 2019-10-03 | |||
| WO2012165546A1 | 2012-12-06 | |||
| WO2020262259A1 | 2020-12-30 | |||
| WO2018021233A1 | 2018-02-01 | |||
| WO2010113939A1 | 2010-10-07 | |||
| WO2020175473A1 | 2020-09-03 | |||
| WO2020175472A1 | 2020-09-03 | |||
| WO2020262259A1 | 2020-12-30 |
Foreign References:
| US20140094567A1 | 2014-04-03 | |||
| JPH06145126A | 1994-05-24 | |||
| JP2019122492A | 2019-07-25 |
Other References:
MASAKI NODA ET AL.: "Application of amino protecting groups in peptide solid-phase synthesis of dibenzosveryl and dibenzosberenyl groups (1st report)", SHIMADZU REVIEW, vol. 54, no. 1, 1 January 1997 (1997-01-01), JP , pages 49 - 53, XP009545736, ISSN: 0371-005X
YONGXIN HAN, SUSAN L. BONTEMS, PETER HEGYES, MARK C. MUNSON, CHARLES A. MINOR, STEVEN A. KATES, FERNANDO ALBERICIO, GEORGE BARANY: "Preparation and Applications of Xanthenylamide (XAL) Handles for Solid-Phase Synthesis of C- Terminal Peptide Amides under Particularly Mild Conditions 1 - 3", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 61, no. 18, 1 January 1996 (1996-01-01), pages 6326 - 6339, XP055064483, ISSN: 00223263, DOI: 10.1021/jo960312d
ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 21, no. 3, 2017, pages 365 - 369
YONGXIN HAN, SUSAN L. BONTEMS, PETER HEGYES, MARK C. MUNSON, CHARLES A. MINOR, STEVEN A. KATES, FERNANDO ALBERICIO, GEORGE BARANY: "Preparation and Applications of Xanthenylamide (XAL) Handles for Solid-Phase Synthesis of C- Terminal Peptide Amides under Particularly Mild Conditions 1 - 3", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 61, no. 18, 1 January 1996 (1996-01-01), pages 6326 - 6339, XP055064483, ISSN: 00223263, DOI: 10.1021/jo960312d
ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 21, no. 3, 2017, pages 365 - 369
Attorney, Agent or Firm:
SIKS & CO. (JP)
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