Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR PRODUCING PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2022/149612
Kind Code:
A1
Abstract:
The present invention provides an industrially suitable, novel method for producing compound (1). The present invention relates to a method for producing compound (1) or a salt thereof, the method being characterized in that compound (13) (in the formula, P1 represents a protecting group) is used as a starting material, and a peptide elongation reaction is advanced toward the N-terminal side.

Inventors:
HAYASHIDA YASUHIRO (JP)
WAKUI KAZUYA (JP)
TERAJIMA YUTA (JP)
Application Number:
PCT/JP2022/000431
Publication Date:
July 14, 2022
Filing Date:
January 07, 2022
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
NISSAN CHEMICAL CORP (JP)
International Classes:
C07K1/02; C07K1/06
Other References:
OKADA YOHEI, TAKASAWA RICO, KUBO DAISUKE, IWANAGA NATSUMI, FUJITA SHUJI, SUZUKI KOSUKE, SUZUKI HIDEAKI, KAMIYA HIDEHIRO, CHIBA KAZ: "Improved Tag-Assisted Liquid-Phase Peptide Synthesis: Application to the Synthesis of the Bradykinin Receptor Antagonist Icatibant Acetate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 23, no. 11, 15 November 2019 (2019-11-15), pages 2576 - 2581, XP055949530, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.9b00397
BORSUK, K. ; VAN DELFT, F.L. ; EGGEN, I.F. ; TEN KORTENAAR, P.B. ; PETERSEN, A. ; RUTJES, F.P.: "Application of substituted 2-(trimethylsilyl)ethyl esters to suppress diketopiperazine formation", TETRAHEDRON LETTERS, vol. 45, no. 18, 26 April 2004 (2004-04-26), pages 3585 - 3588, XP027092766, ISSN: 0040-4039
AMBLARD MURIEL; FEHRENTZ JEAN-ALAIN; MARTINEZ JEAN; SUBRA GILLES: "Methods and Protocols of modern solid phase peptide synthesis", MOLECULAR BIOTECHNOLOGY, vol. 33, no. 3, 1 July 2006 (2006-07-01), pages 239 - 254, XP009116689, ISSN: 1073-6085, DOI: 10.1385/MB:33:3:239
ALBERT ISIDRO-LLOBET, ALVAREZ MERCEDES, ALBERICIO FERNANDO: "Amino Acid-Protecting Groups", CHEMICAL REVIEWS, vol. 109, no. 6, 10 June 2009 (2009-06-10), pages 2455 - 2504, XP055081001, ISSN: 00092665, DOI: 10.1021/cr800323s
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
Download PDF: