Title:
METHOD FOR PRODUCING RADIOACTIVE METAL COMPLEX
Document Type and Number:
WIPO Patent Application WO/2021/033530
Kind Code:
A1
Abstract:
This method for producing a radioactive metal complex comprises a step for reacting a radioactive metal with DOTA or a ligand, which is a derivative of DOTA, in a reaction solution to form a radioactive metal complex. The reaction solution contains water, a buffer, and a water-soluble organic solvent. The radioactive metal is 89Zr or 225Ac. The ligand may have a group linked to a peptide in the structure thereof. It is also preferable that the content of the water-soluble organic solvent contained in the reaction solution be 2-50 vol%. It is also preferable to react the radioactive metal with the ligand in the reaction solution at a temperature of 30-80°C.
More Like This:
Inventors:
IMAI TOMOYUKI (JP)
KIRIU MASATO (JP)
IZAWA AKIHIRO (JP)
KIRIU MASATO (JP)
IZAWA AKIHIRO (JP)
Application Number:
PCT/JP2020/029757
Publication Date:
February 25, 2021
Filing Date:
August 04, 2020
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
International Classes:
C07D257/02; C07D403/12; C07D403/14; C07F5/00; C07F7/00
Domestic Patent References:
| WO2018187631A1 | 2018-10-11 | |||
| WO2008009444A1 | 2008-01-24 | |||
| WO2017161356A1 | 2017-09-21 |
Foreign References:
| JP2017503763A | 2017-02-02 | |||
| JP2007535492A | 2007-12-06 | |||
| JP2013512918A | 2013-04-18 | |||
| JP2004532820A | 2004-10-28 | |||
| US20140147381A1 | 2014-05-29 | |||
| US20050191239A1 | 2005-09-01 | |||
| JP2019151480A | 2019-09-12 |
Other References:
PÉREZ-MALO MARYLAINE, SZABÓ GERGELY, EPPARD ELISABETH, VAGNER ADRIENN, BRÜCHER ERNŐ, TÓTH IMRE, MAIOCCHI ALESSANDRO, SUH EUL HYUN,: "Improved Efficacy of Synthesizing *MIII- Labeled DOTA Complexes in Binary Mixtures of Water and Organic Solvents", A COMBINED RADIO- AND PHYSICOCHEMICAL STUDY, INORGANIC CHEMISTRY, vol. 57, no. 10, 10 May 2018 (2018-05-10), pages 6107 - 6117, XP055803247, ISSN: 0020-1669
HASEGAWA KOKI, KAWACHI EMI, UEHARA YOSHINARI, YOSHIDA TSUYOSHI, IMAIZUMI SATOSHI, OGAWA MASAHIRO, MIURA SHIN-ICHIRO, SAKU KEIJIRO: "Improved 68Ga-labeling method using ethanol addition: Application to the alpha-helical peptide DOTA-FAMP", J LABEL COMPD RADIOPHARM, vol. 60, no. 1, January 2017 (2017-01-01), pages 55 - 61, XP055803249, ISSN: 1099-1344
GHAI ANCHAL, SINGH BALJINDER, LI MENGSHI, DANIELS TAMARA A., COELHO RICHARD, ORCUTT KELLY, WATKINS G. LEONARD, NORENBERG JEFFREY P: "Optimizing the radiosynthesis of [68Ga] DOTA-MLN6907 peptide containing three disulfide cyclization bonds - a GCC specific chelate for clinical radiopharmaceuticals", APPLIED RADIATION AND ISOTOPES, vol. 140, October 2018 (2018-10-01), pages 333 - 341, XP055803251, ISSN: 0969-8043
PANDYA ET AL., CHEM SCI, vol. 8, no. 3, 2017, pages 2309 - 14
EPPARD ET AL., EJNMMI RADIOPHARM. CHEM., vol. 1, 2017, pages 6
PEREZ-MALO ET AL., INORG. CHEM., vol. 57, no. 10, 2018, pages 6107 - 6117
HASEGAWA KOKI, KAWACHI EMI, UEHARA YOSHINARI, YOSHIDA TSUYOSHI, IMAIZUMI SATOSHI, OGAWA MASAHIRO, MIURA SHIN-ICHIRO, SAKU KEIJIRO: "Improved 68Ga-labeling method using ethanol addition: Application to the alpha-helical peptide DOTA-FAMP", J LABEL COMPD RADIOPHARM, vol. 60, no. 1, January 2017 (2017-01-01), pages 55 - 61, XP055803249, ISSN: 1099-1344
GHAI ANCHAL, SINGH BALJINDER, LI MENGSHI, DANIELS TAMARA A., COELHO RICHARD, ORCUTT KELLY, WATKINS G. LEONARD, NORENBERG JEFFREY P: "Optimizing the radiosynthesis of [68Ga] DOTA-MLN6907 peptide containing three disulfide cyclization bonds - a GCC specific chelate for clinical radiopharmaceuticals", APPLIED RADIATION AND ISOTOPES, vol. 140, October 2018 (2018-10-01), pages 333 - 341, XP055803251, ISSN: 0969-8043
PANDYA ET AL., CHEM SCI, vol. 8, no. 3, 2017, pages 2309 - 14
EPPARD ET AL., EJNMMI RADIOPHARM. CHEM., vol. 1, 2017, pages 6
PEREZ-MALO ET AL., INORG. CHEM., vol. 57, no. 10, 2018, pages 6107 - 6117
Attorney, Agent or Firm:
SHOWA INTERNATIONAL PATENT FIRM (JP)
Download PDF: