Title:
METHOD FOR PRODUCING RECOMBINANT ACREMONIUM CHRYSOGENUM STRAIN PRODUCING 7-AMINOCEPHALOSPORANIC ACID AT HIGH CONCENTRATION, AND STRAIN PRODUCED USING METHOD
Document Type and Number:
WIPO Patent Application WO/2018/038577
Kind Code:
A8
Abstract:
The present invention relates to a method for producing a recombinant Acremonium chrysogenum strain which produces 7-aminocephalosporanic acid at a high concentration, and to a strain produced using the method. More specifically, the present invention relates to: a method for producing an Acremonium chrysogenum strain which has a high 7-ACA production capability; a recombinant Acremonium chrysogenum strain produced using the method; a method for producing 7-ACA, wherein the strain is cultured under conditions capable of producing 7-ACA and collected; a promoter for highly expressing protein in an Acremonium chrysogenum strain used in the method for producing 7-ACA; an expression vector for highly expressing CPC acylase in an Acremonium chrysogenum strain; a use of the strain in the production of 7-ACA; a use of the produced 7-ACA in the production of an antibiotic agent; and a method for treating bacterial infectious diseases, wherein the method comprises administering the 7-ACA. According to the method of the present invention, 7-ACA can be produced at a high concentration by producing a recombinant Acremonium chrysogenum strain and fermenting the same.
Inventors:
SHIN YONG CHUL (KR)
PIAO ZHE (KR)
YOON SANG HWAL (KR)
LEE HYEON SEO (KR)
CHOI YEON HEE (KR)
KIM EUN JUNG (KR)
PIAO ZHE (KR)
YOON SANG HWAL (KR)
LEE HYEON SEO (KR)
CHOI YEON HEE (KR)
KIM EUN JUNG (KR)
Application Number:
PCT/KR2017/009330
Publication Date:
February 21, 2019
Filing Date:
August 25, 2017
Export Citation:
Assignee:
AMICOGEN INC (KR)
International Classes:
C12N15/80; C12N9/80; C12P35/06
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
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