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Title:
METHOD AND REAGENT FOR DETECTING MALIGNANT OVARIAN TUMORS
Document Type and Number:
WIPO Patent Application WO/2021/172000
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for detecting malignant ovarian tumors distinctly from benign ovarian tumors and a reagent that can be used in the method. This method for detecting malignant ovarian tumors (excluding high-grade serous carcinoma) distinctly from benign ovarian tumors is characterized in that the amount of TFPI2 in a sample originating from a patient is measured. In addition, an antibody that specifically recognizes TFPI2 processing polypeptide and intact TPFI2 is included in a reagent for detecting malignant ovarian tumors (excluding high-grade serous carcinoma) distinctly from benign ovarian tumors.

Inventors:
MIYAGI ETSUKO (JP)
ARAKAWA NORIAKI (JP)
OHTAKE NORIHISA (JP)
MYOBA SHOHEI (JP)
Application Number:
PCT/JP2021/004736
Publication Date:
September 02, 2021
Filing Date:
February 09, 2021
Export Citation:
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Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
TOSOH CORP (JP)
International Classes:
G01N33/574
Domestic Patent References:
WO2016084912A12016-06-02
Foreign References:
JP2012145500A2012-08-02
JP2013061321A2013-04-04
JP2007506965A2007-03-22
US20050037389A12005-02-17
US20050095592A12005-05-05
EP3657170A12020-05-27
Other References:
INABA N, ISHIGE H, IJICHI M, SATOH N, OHKAWA R, SEKIYA S, SHIROTAKE S, TAKAMIZAWA H, RENK T, BOHN H: "IMMUNO HISTOCHEMICAL DETECTION OF PREGNANCY SPECIFIC PROTEIN SP-1 AND PLACENTA SPECIFIC TISSUE PROTEINS PP-5 PP-10 PP-11 AND PP-12 IN OVARIAN ADENO CARCINOMAS", ONCODEVELOPMENT BIOLOGY AND MEDICINE, ELSEVIER, AMSTERDAM,, NL, vol. 3, no. 5-6, 1 January 1982 (1982-01-01), NL, pages 379 - 390, XP009140970, ISSN: 0167-1618
BOLTENBERG A, FURGYIK S: "PLACENTAL PROTEINS (PP 5, PP 12 AND PP 14) IN OVARIAN TUMORS A PRELIMINARY REPORT", ACTA OBSTETRICIA AND GYNECOLOGICA SCANDINAVICA., MUNKSGAARD, COPENHAGEN., DK, vol. 66, no. 03, 1 January 1987 (1987-01-01), DK, pages 213 - 215, XP000990701, ISSN: 0001-6349
ZHANG, QING ET AL.: "A multiplex methylation- specific PCR assay for the detection of early- stage ovarian cancer using cell -free serum DNA", CYNECOLOGIC ONCOLOGY, vol. 130, 2013, pages 132 - 139, XP028569267, DOI: 10.1016/j.ygyno.2013.04.048
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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