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Patent Searching and Data


Title:
METHOD FOR REFINING DIENOGEST
Document Type and Number:
WIPO Patent Application WO/2022/142385
Kind Code:
A1
Abstract:
The present invention provides a method for refining dienogest. The method is a recrystallization method. The present invention belongs to the technical field of medicine synthesis. The refining of dienogest comprises the following steps: step (1): dissolving a dienogest crude product in a mixed solution of an organic solvent and water; step (2): heating to dissolve the dienogest crude product; and step (3): cooling and crystallizing to obtain a refined product of dienogest. Compared with the existing technology, the present invention features a simple purification process, a high yield of dienogest, a low impurity content, and less solvent consumption, and is suitable for industrial application.

Inventors:
LI WENHUA (CN)
LIU HAIZHU (CN)
Application Number:
PCT/CN2021/113556
Publication Date:
July 07, 2022
Filing Date:
August 19, 2021
Export Citation:
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Assignee:
SHANGHAI HUILUN BIOLOGICAL TECH CO LTD (CN)
SHANGHAI HUILUN JIANGSU PHARMACEUTICAL CO LTD (CN)
International Classes:
C07J41/00; A61P5/30; A61P15/00; A61P15/18; C07B63/00; C07B63/04
Foreign References:
CN112724191A2021-04-30
CN102718828A2012-10-10
CN110655551A2020-01-07
Other References:
XU JUAN, LI PENG, CHEN XIAOFENG, WANG HUIPING, NING LIFENG: "Measurement and Correlation of the Solubility of Dienogest in Twelve Pure and Water + Methanol Binary Solvents at Temperatures from 273.15 to 318.15 K", JOURNAL OF CHEMICAL AND ENGINEERING DATA., vol. 64, no. 10, 10 October 2019 (2019-10-10), US , pages 4580 - 4591, XP055947685, ISSN: 0021-9568, DOI: 10.1021/acs.jced.9b00696
Attorney, Agent or Firm:
HANGZHOU CRESUN INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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