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Title:
METHOD FOR SCREENING FOR AUTOPHAGY REGULATOR TARGETING GLYCOSYLATION OF ULK1 PROTEIN
Document Type and Number:
WIPO Patent Application WO/2020/256230
Kind Code:
A1
Abstract:
A method, of the present invention, based on a mechanism in which O-GlcNAcylated ULK1, according to the present application, plays a crucial role in binding to ATG14L so as to induce the phosphorylation thereof, which is followed by the activation of VPS34 and subsequently leading to phagophore formation and initiation of autophagy, caused by an increase in PI3P, can be effectively used as a target for the development of new drugs for treatment of autophagy-related diseases. Particularly, O-GlcNAcylation of ULK1 has been found to contribute to early progression of autophagosomes rather than the fusion of autophagosomes and lysosomes, and thus can be used in the development of new drugs that are useful for early regulation of autophagy progression.

Inventors:
BAEK SUNG HEE (KR)
PYO KI EUN (KR)
KIM KEUN IL (KR)
Application Number:
PCT/KR2019/014675
Publication Date:
December 24, 2020
Filing Date:
November 01, 2019
Export Citation:
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Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
G01N33/50; G01N33/68
Foreign References:
KR101796479B12017-11-13
KR101645359B12016-08-05
KR100988999B12010-10-20
Other References:
PYO, KI EUN: "Studies on the Regulation of Autophagy Initiation by ULK1 0-G1cNAcylation", DOCT. THESIS, SCHOOL OF BIOLOG SCIENCES SEOUL, August 2018 (2018-08-01), pages 1 - 95, XP055773962
DATABASE Protein 19 August 1998 (1998-08-19), KUROYANAGI, H. ET AL.: "serine/threonine kinase ULK1 [Homo sapiens", XP002214557, retrieved from NCBI Database accession no. AAC32326.1
PYO, KI EUN, KIM CHANG ROK, LEE MINKYOUNG, KIM JONG-SEO, KIM KEUN IL, BAEK SUNG HEE: "ULK1 0-GtcNAcytation is crucial for activating VPS34 via ATG 14L during autophagy initiation", CELL REPORTS, vol. 25, no. 10, 4 December 2018 (2018-12-04), pages 2878 - 2890, XP055773977, DOI: 10.1016/j.celrep.2018.11.042
Attorney, Agent or Firm:
PARK, Weonmee (KR)
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