Title:
METHOD FOR SCREENING DIABETES TREATING AGENT
Document Type and Number:
WIPO Patent Application WO/2012/015249
Kind Code:
A2
Abstract:
The present invention provides a method for screening a diabetes treating agent comprising the following steps: (a) preparing cells inside a culture medium; (b) treating the culture medium with a test substance; (c) treating the result of step (b) with a glucose derivative which is not metabolized; and (d) measuring the glucose derivative which has flowed into the cells, wherein the test substance is determined to be a diabetes treating agent if the test substance accelerates uptake of the glucose derivative in the cells. Therefore, the described pharmaceutical composition, including a triazin-based compound as an active ingredient, can be useful for application in preventing or treating diabetes.
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Inventors:
WILLIAMS DARREN R (KR)
JUNG DA-WOON (KR)
CHANG YOUNG-TAE (KR)
JUNG DA-WOON (KR)
CHANG YOUNG-TAE (KR)
Application Number:
PCT/KR2011/005553
Publication Date:
February 02, 2012
Filing Date:
July 28, 2011
Export Citation:
Assignee:
KWANGJU INST SCI & TECH (KR)
WILLIAMS DARREN R (KR)
JUNG DA-WOON (KR)
CHANG YOUNG-TAE (KR)
WILLIAMS DARREN R (KR)
JUNG DA-WOON (KR)
CHANG YOUNG-TAE (KR)
International Classes:
G01N33/15; A61K31/53; C12Q1/54; C40B30/06
Domestic Patent References:
| WO2003032903A2 | 2003-04-24 | |||
| WO2003050237A2 | 2003-06-19 |
Foreign References:
| JPH10267914A | 1998-10-09 | |||
| JP2005312364A | 2005-11-10 | |||
| KR20090023245A | 2009-03-04 | |||
| KR20080088630A | 2008-10-02 |
Other References:
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M. NISHIDE; Y. YOSHIKAWA; E. U. YOSHIKAWA; K. MATSUMOTO; H. SAKURAI; N. M. KAJIWARA, CHEM PHARM BULL, vol. 56, 2008, pages 1181 - 1183
B. ZHANG; G. SALITURO; D. SZALKOWSKI; Z. LI; Y. ZHANG; I. ROYO; D. VILELLA; M. T DIEZ; F. PELAEZ; C. RUBY, SCIENCE, vol. 284, 1999, pages 974 - 977
W. L. LI; H. C. ZHENG; J. BUKURU; N. DE KIMPE, J ETHNOPHARMACOL, vol. 92, 2004, pages 1 - 21
N. MALVIYA; S. JAIN; S. MALVIYA, ACTA POL PHARM, vol. 67, 2010, pages 113 - 118
L. F. BARROS; M. YOUNG; J. SAKLATVALA; S. A. BALDWIN, J PHYSIOL, vol. 504, no. 3, 1997, pages 517 - 525
L. SPEIZER; R. HAUGLAND; H. KUTCHAI, BIOCHIM BIOPHYS ACTA, vol. 815, 1985, pages 75 - 84
K. YOSHIOKA; H. TAKAHASHI; T HOMMA; M. SAITO; K. B. OH; Y. NEMOTO; H. MATSUOKA, BIOCHIM BIOPHYS ACTA, vol. 1289, 1996, pages 5 - 9
L. F. BARROS; C. X. BITTNER; A. LOAIZA; I. RUMINOT; V. LARENAS; H. MOLDENHAUER; C. OYARZUN; M. ALVAREZ, J NEUROCHEM, vol. 109, 2009, pages 94 - 100
G. DIMITRIADIS; E. MARATOU; E. BOUTATI; K. PSARRA; C. PAPASTERIADES; S. A. RAPTIS, CYTOMETRY A, vol. 64, 2005, pages 27 - 33
C. ZOU; Y. WANG; Z. SHEN, BIOCHEM BIOPHYS METHODS, vol. 64, 2005, pages 207 - 215
F. LEIRA; M. C. LOUZAO; J. M. VIEITES; L. M. BOTANA; M. R. VIEYTES, TOXICOL IN VITRO, vol. 16, 2002, pages 267 - 273
M. NAKAI; F. SEKIGUCHI; M. OBATA; C. OHTSUKI; Y. ADACHI; H. SAKURAI; C. ORVIG; D. REHDER; S. YANO, J INORG BIOCHEM, vol. 99, 2005, pages 1275 - 1282
J. KIM; K. H. NAM; S. O. KIM; J. H. CHOI; H. C. KIM; S. D. YANG; J. H. KANG; Y. H. RYU; G. T OH; S. E. YOO, FASEB J, vol. 18, 2004, pages 714 - 716
D. E. JAMES; M. STRUBE; M. MUECKLER, NATURE, vol. 338, 1989, pages 83 - 87
W. B. PARKER; J. A. SECRIST, 3RD; W. R. WAUD, CURR OPIN INVESTIG DRUGS, vol. 5, 2004, pages 592 - 596
S. A. BALDWIN; L. F. BARROS; M. GRIFFITHS; J. INGRAM; E. C. ROBBINS; A. J. STREETS; J. SAKLATVALA, BIOCHEM SOC TRANS, vol. 25, 1997, pages 954 - 958
K. KAWABE; Y. YOSHIKAWA; Y. ADACHI; H. SAKURAI, LIFE SCI, vol. 78, 2006, pages 2860 - 2866
A. J. ALONSO-CASTRO; R. ZAPATA-BUSTOS; J. ROMO-YANEZ; P. CAMARILLO-LEDESMA; M. GOMEZ-SANCHEZ; L. A. SALAZAR-OLIVO, J ETHNOPHARMACOL, vol. 127, 2010, pages 1 - 6
G. S. HOTAMISLIGIL; D. L. MURRAY; L. N. CHOY; B. M. SPIEGELMAN, PROC NATL ACAD SCI USA, vol. 91, 1994, pages 4854 - 4858
A. GARCIA DE HERREROS; M. J. BIRNBAUM, J BIOL CHEM, vol. 264, 1989, pages 19994 - 19999
G. E. MANN; B. BONACASA; T ISHII; R. C. SIOW, CURR OPIN PHARMACOL, vol. 9, 2009, pages 139 - 145
S. H. KIM; M. CHOI; Y. LEE; Y. O. KIM; D. S. AHN; Y. H. KIM; E. S. KANG; E. J. LEE; M. JUNG; J. W. CHO, CARDIOVASC RES, 2010
R. J. ESPER; J. O. VILARINO; R. A. MACHADO; A. PARAGANO, ADV CARDIOL, vol. 45, 2008, pages 17 - 43
K. YONEKAWA; J. M. HARLAN, J LEUKOC BIOL, vol. 77, 2005, pages 129 - 140
G. LI; E. J. BARRETT; S. H. KO; W. CAO; Z. LIU, ENDOCRINOLOGY, vol. 150, 2009, pages 3475 - 3482
S. R. MILLON; J. H. OSTRANDER; J. Q. BROWN; A. RAHEJA; V. L. SEEWALDT; N. RAMANUJAM, BREAST CANCER RES TREAT, 2010
N. NITIN; A. L. CARLSON; T. MULDOON; A. K. EI-NAGGAR; A. GILLENWATER; R. RICHARDS-KORTUM, INT J CANCER, vol. 124, 2009, pages 2634 - 2642
A. UEYAMA; K. L. YAWORSKY; Q. WANG; Y. EBINA; A. KLIP, AM J PHYSIOL, vol. 277, 1999, pages E572 - 578
D. WILLIAMS; D. W. JUNG; S. M. KHERSONSKY; N. HEIDARY; Y. T CHANG; S. J. ORLOW, CHEM BIOL, vol. 11, 2004, pages 1251 - 1259
J. R. SNYDER; A. HALL; L. NI-KOMATSU; S. M. KHERSONSKY; Y. T CHANG; S. J. ORLOW, CHEM BIOL, vol. 12, 2005, pages 477 - 484
R. KLEEMANN; L. VERSCHUREN; B. J. DE ROOIJ; J. LINDEMAN; M. M. DE MAAT; A. J. SZALAI; H. M. PRINCEN; T KOOISTRA, BLOOD, vol. 103, 2004, pages 4188 - 4194
See also references of EP 2600147A4
M. NISHIDE; Y. YOSHIKAWA; E. U. YOSHIKAWA; K. MATSUMOTO; H. SAKURAI; N. M. KAJIWARA, CHEM PHARM BULL, vol. 56, 2008, pages 1181 - 1183
B. ZHANG; G. SALITURO; D. SZALKOWSKI; Z. LI; Y. ZHANG; I. ROYO; D. VILELLA; M. T DIEZ; F. PELAEZ; C. RUBY, SCIENCE, vol. 284, 1999, pages 974 - 977
W. L. LI; H. C. ZHENG; J. BUKURU; N. DE KIMPE, J ETHNOPHARMACOL, vol. 92, 2004, pages 1 - 21
N. MALVIYA; S. JAIN; S. MALVIYA, ACTA POL PHARM, vol. 67, 2010, pages 113 - 118
L. F. BARROS; M. YOUNG; J. SAKLATVALA; S. A. BALDWIN, J PHYSIOL, vol. 504, no. 3, 1997, pages 517 - 525
L. SPEIZER; R. HAUGLAND; H. KUTCHAI, BIOCHIM BIOPHYS ACTA, vol. 815, 1985, pages 75 - 84
K. YOSHIOKA; H. TAKAHASHI; T HOMMA; M. SAITO; K. B. OH; Y. NEMOTO; H. MATSUOKA, BIOCHIM BIOPHYS ACTA, vol. 1289, 1996, pages 5 - 9
L. F. BARROS; C. X. BITTNER; A. LOAIZA; I. RUMINOT; V. LARENAS; H. MOLDENHAUER; C. OYARZUN; M. ALVAREZ, J NEUROCHEM, vol. 109, 2009, pages 94 - 100
G. DIMITRIADIS; E. MARATOU; E. BOUTATI; K. PSARRA; C. PAPASTERIADES; S. A. RAPTIS, CYTOMETRY A, vol. 64, 2005, pages 27 - 33
C. ZOU; Y. WANG; Z. SHEN, BIOCHEM BIOPHYS METHODS, vol. 64, 2005, pages 207 - 215
F. LEIRA; M. C. LOUZAO; J. M. VIEITES; L. M. BOTANA; M. R. VIEYTES, TOXICOL IN VITRO, vol. 16, 2002, pages 267 - 273
M. NAKAI; F. SEKIGUCHI; M. OBATA; C. OHTSUKI; Y. ADACHI; H. SAKURAI; C. ORVIG; D. REHDER; S. YANO, J INORG BIOCHEM, vol. 99, 2005, pages 1275 - 1282
J. KIM; K. H. NAM; S. O. KIM; J. H. CHOI; H. C. KIM; S. D. YANG; J. H. KANG; Y. H. RYU; G. T OH; S. E. YOO, FASEB J, vol. 18, 2004, pages 714 - 716
D. E. JAMES; M. STRUBE; M. MUECKLER, NATURE, vol. 338, 1989, pages 83 - 87
W. B. PARKER; J. A. SECRIST, 3RD; W. R. WAUD, CURR OPIN INVESTIG DRUGS, vol. 5, 2004, pages 592 - 596
S. A. BALDWIN; L. F. BARROS; M. GRIFFITHS; J. INGRAM; E. C. ROBBINS; A. J. STREETS; J. SAKLATVALA, BIOCHEM SOC TRANS, vol. 25, 1997, pages 954 - 958
K. KAWABE; Y. YOSHIKAWA; Y. ADACHI; H. SAKURAI, LIFE SCI, vol. 78, 2006, pages 2860 - 2866
A. J. ALONSO-CASTRO; R. ZAPATA-BUSTOS; J. ROMO-YANEZ; P. CAMARILLO-LEDESMA; M. GOMEZ-SANCHEZ; L. A. SALAZAR-OLIVO, J ETHNOPHARMACOL, vol. 127, 2010, pages 1 - 6
G. S. HOTAMISLIGIL; D. L. MURRAY; L. N. CHOY; B. M. SPIEGELMAN, PROC NATL ACAD SCI USA, vol. 91, 1994, pages 4854 - 4858
A. GARCIA DE HERREROS; M. J. BIRNBAUM, J BIOL CHEM, vol. 264, 1989, pages 19994 - 19999
G. E. MANN; B. BONACASA; T ISHII; R. C. SIOW, CURR OPIN PHARMACOL, vol. 9, 2009, pages 139 - 145
S. H. KIM; M. CHOI; Y. LEE; Y. O. KIM; D. S. AHN; Y. H. KIM; E. S. KANG; E. J. LEE; M. JUNG; J. W. CHO, CARDIOVASC RES, 2010
R. J. ESPER; J. O. VILARINO; R. A. MACHADO; A. PARAGANO, ADV CARDIOL, vol. 45, 2008, pages 17 - 43
K. YONEKAWA; J. M. HARLAN, J LEUKOC BIOL, vol. 77, 2005, pages 129 - 140
G. LI; E. J. BARRETT; S. H. KO; W. CAO; Z. LIU, ENDOCRINOLOGY, vol. 150, 2009, pages 3475 - 3482
S. R. MILLON; J. H. OSTRANDER; J. Q. BROWN; A. RAHEJA; V. L. SEEWALDT; N. RAMANUJAM, BREAST CANCER RES TREAT, 2010
N. NITIN; A. L. CARLSON; T. MULDOON; A. K. EI-NAGGAR; A. GILLENWATER; R. RICHARDS-KORTUM, INT J CANCER, vol. 124, 2009, pages 2634 - 2642
A. UEYAMA; K. L. YAWORSKY; Q. WANG; Y. EBINA; A. KLIP, AM J PHYSIOL, vol. 277, 1999, pages E572 - 578
D. WILLIAMS; D. W. JUNG; S. M. KHERSONSKY; N. HEIDARY; Y. T CHANG; S. J. ORLOW, CHEM BIOL, vol. 11, 2004, pages 1251 - 1259
J. R. SNYDER; A. HALL; L. NI-KOMATSU; S. M. KHERSONSKY; Y. T CHANG; S. J. ORLOW, CHEM BIOL, vol. 12, 2005, pages 477 - 484
R. KLEEMANN; L. VERSCHUREN; B. J. DE ROOIJ; J. LINDEMAN; M. M. DE MAAT; A. J. SZALAI; H. M. PRINCEN; T KOOISTRA, BLOOD, vol. 103, 2004, pages 4188 - 4194
See also references of EP 2600147A4
Attorney, Agent or Firm:
YANG, Boo-Hyun (1659-2 Inhundong Gwanak-gu, Seoul 151-832, KR)
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