Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR SCREENING INFLAMMATORY BOWEL DISEASE THERAPEUTIC AGENT TARGETING RORα
Document Type and Number:
WIPO Patent Application WO/2021/091009
Kind Code:
A1
Abstract:
The present application discloses a method for screening an inflammatory bowel disease therapeutic agent on the basis of a mechanism in which RORα inhibits NF-κB transcriptional activity in the bowels, thereby inhibiting the expression of inflammatory genes, and consequently, can regulate inflammatory responses. A candidate material discovered by the screening method according to the present application maintains the balance of inflammatory responses, and thus, can be effectively used in the treatment of inflammatory diseases, including inflammatory bowel disease.

Inventors:
BAEK SUNG HEE (KR)
KIM DONGHA (KR)
OH SE-GYU (KR)
FANG SUNGSOON (KR)
PARK DAECHAN (KR)
Application Number:
PCT/KR2019/016833
Publication Date:
May 14, 2021
Filing Date:
December 02, 2019
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
UNIV YONSEI IACF (KR)
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
C12Q1/6883; A61K31/166; A61K31/18; A61K38/17; A61P1/00; A61P29/00
Domestic Patent References:
WO2011115892A12011-09-22
Foreign References:
KR20130105545A2013-09-25
KR101894670B12018-09-04
JP2004507246A2004-03-11
KR20160132534A2016-11-21
Other References:
OH SE KYU, KIM DONGHA, KIM KYEONGKYU, BOO KYUNGJIN, YU YOUNG SUK, KIM IK SOO, JEON YOON, IM SUN-KYOUNG, LEE SU-HYUNG, LEE JI MIN, : "RORa is crucial for attenuated inflammatory response to maintain intestinal OH, homeostasis", PNAS, vol. 116, no. 42, 15 October 2019 (2019-10-15), pages 21140 - 21149, XP055821348
Attorney, Agent or Firm:
PARK, Weonmee (KR)
Download PDF: