Title:
METHOD FOR SELECTIVELY KILLING PROTEIN AGGREGATE-CONTAINING CELLS, KIT THEREFOR, THERAPEUTIC DRUG FOR PROTEIN MISFOLDING DISEASES AND DRUG PRODUCT FOR REMOVING PROTEIN AGGREGATES FROM BLOOD PRODUCT
Document Type and Number:
WIPO Patent Application WO/2021/090911
Kind Code:
A1
Abstract:
Provided are: a method for selectively killing protein aggregate-containing cells; a kit therefor; a therapeutic drug for protein misfolding diseases; and a drug product for removing protein aggregates from a blood product. The method for selectively killing protein aggregate-containing cells according to one embodiment comprises treating cells with a molecular structure-modifying agent, the molecular structure-modifying agent containing a fluoroalcohol or a compound represented by general formula (1) as a compound detecting protein aggregates, and thus selectively killing protein aggregate-containing cells. [In general formula (1): a is 0 or 1; when a is 1, then R1 is a hydrogen atom and R2 is a hydroxyl group, or R1 is a hydroxyl group and R2 is a hydrogen atom; when a is 0, then R2 is an oxygen atom forming a double bond together with a carbon atom; R3 is CHlClmFn; l, m and n are an integer of from 1 to 3, provided that l+m+n equals to 3; R4 is CHsCltFu; and s, t and u are an integer of from 1 to 3, provided that s+t+u equals 3.]
Inventors:
OGAWA TSUYOSHI (JP)
Application Number:
PCT/JP2020/041522
Publication Date:
May 14, 2021
Filing Date:
November 06, 2020
Export Citation:
Assignee:
CENTRAL GLASS CO LTD (JP)
International Classes:
A61K31/045; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P27/12; A61P43/00
Foreign References:
| JP2002534681A | 2002-10-15 | |||
| JP2018035099A | 2018-03-08 | |||
| JP2009013126A | 2009-01-22 | |||
| JP2010131717A | 2010-06-17 | |||
| JP2009029752A | 2009-02-12 | |||
| JP2009167128A | 2009-07-30 |
Other References:
WILLE HOLGER, PRUSINER STANLEY B., COHEN FRED E.: "Scrapie infectivity is independent of amyloid staining properties of the n-terminally truncated prion protein", JOURNAL OF STRUCTURAL BIOLOGY, vol. 130, no. 2-3, 2000, pages 323 - 338, XP055821758
RUIZ-RIQUELME, A.; WATTS, J.: "Factors controlling the formation of self-propagating ab aggregates", NEURODEGENERATIVE DISEASES, vol. 17, no. 1, 30 November 2016 (2016-11-30), CH , pages 627, XP009536870, ISSN: 1660-2854
HIDEHIRO MIZUSAWA: "Prions and prion diseases", PHARMA MEDICA, vol. 35, no. 2, 2017, pages 67 - 69
KENTARO SAHASHI: "Targeted therapeutic approaches for aggregation-prone proteins", SEITAI NO KAGAKU, vol. 67, no. 4, 2016, pages 296 - 302
TATSUO YAMADAKATSUMI DOH-URA: "Qinacrine treatment for Creutzfeldt-Jakob disease, H15 Research report of the research on prion disease and slow virus infection in the specific disease countermeasure research project of the Ministry of Health", LABOR AND WELFARE SCIENTIFIC RESEARCH GRANT, 2004, pages 113 - 124
TSUBOI YDOH-URA KYAMADA T. ET AL.: "Continuous intraventricular infusion of pentsan polysulfate: clinical trial against prion diseases", NEUROPATHOLOGY, vol. 29, 2009, pages 362 - 636
JEREMY ROBERTSON: "Protecting Group Chemistry", OXFORD UNIVERSITY PRESS
See also references of EP 4056175A4
RUIZ-RIQUELME, A.; WATTS, J.: "Factors controlling the formation of self-propagating ab aggregates", NEURODEGENERATIVE DISEASES, vol. 17, no. 1, 30 November 2016 (2016-11-30), CH , pages 627, XP009536870, ISSN: 1660-2854
HIDEHIRO MIZUSAWA: "Prions and prion diseases", PHARMA MEDICA, vol. 35, no. 2, 2017, pages 67 - 69
KENTARO SAHASHI: "Targeted therapeutic approaches for aggregation-prone proteins", SEITAI NO KAGAKU, vol. 67, no. 4, 2016, pages 296 - 302
TATSUO YAMADAKATSUMI DOH-URA: "Qinacrine treatment for Creutzfeldt-Jakob disease, H15 Research report of the research on prion disease and slow virus infection in the specific disease countermeasure research project of the Ministry of Health", LABOR AND WELFARE SCIENTIFIC RESEARCH GRANT, 2004, pages 113 - 124
TSUBOI YDOH-URA KYAMADA T. ET AL.: "Continuous intraventricular infusion of pentsan polysulfate: clinical trial against prion diseases", NEUROPATHOLOGY, vol. 29, 2009, pages 362 - 636
JEREMY ROBERTSON: "Protecting Group Chemistry", OXFORD UNIVERSITY PRESS
See also references of EP 4056175A4
Attorney, Agent or Firm:
TAKAHASHI, HAYASHI AND PARTNER PATENT ATTORNEYS, INC. (JP)
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