Title:
METHOD AND SUBSTANCES FOR DIAGNOSIS AND THERAPY OF SEPSIS AND SEPSIS-LIKE SYSTEMIC INFECTIONS
Document Type and Number:
WIPO Patent Application WO2000022439
Kind Code:
A3
Abstract:
The invention relates to applications of recombinant procalcitonin 3-116 for the diagnosis and therapy of septic diseases and to the measurement of prohormones different from procalcitonin and dipeptidyl peptiodase IV as biomarker in the diagnosis of sepsis.
More Like This:
Inventors:
BERGMANN ANDREAS (DE)
STRUCK JOACHIM (DE)
WEGLOEHNER WOLFGANG (DE)
STRUCK JOACHIM (DE)
WEGLOEHNER WOLFGANG (DE)
Application Number:
PCT/EP1999/007692
Publication Date:
November 16, 2000
Filing Date:
October 13, 1999
Export Citation:
Assignee:
BRAHMS DIAGNOSTICA GMBH (DE)
BERGMANN ANDREAS (DE)
STRUCK JOACHIM (DE)
WEGLOEHNER WOLFGANG (DE)
BERGMANN ANDREAS (DE)
STRUCK JOACHIM (DE)
WEGLOEHNER WOLFGANG (DE)
International Classes:
A61P29/00; C07K14/585; C12N15/09; C12N15/16; G01N33/53; C12P21/02; C12Q1/37; G01N33/74; C12R1/19; (IPC1-7): G01N33/74; C07K14/585; A61K38/23; A61K38/22
Foreign References:
| DE4227454C1 | 1994-02-03 |
Other References:
OKAHARA S ET AL: "SERUM PRO-GASTRIN-RELEASING PEPTIDE (PROGRP) IN SUBJECTS WITH OR WITHOUT HERICOBACTER PYLORI INFECTION", GASTROENTEROLOGY,US,ELSEVIER, NEW YORK, NY,, vol. 110, no. 4, April 1996 (1996-04-01), pages A217, XP000884904, ISSN: 0016-5085
NORIHARU SHIJUBO ET AL: "ELEVATED PROGASTRIN-RELEASING PEPTIDE (31-98) CONCENTRATIONS IN PLEURAL EFFUSIONS DUE TO SMALL-CELL LUNG CARCINOMA", RESPIRATION,CH,KARGER, BASEL, vol. 63, no. 2, 1 March 1996 (1996-03-01), pages 106 - 110, XP000608937, ISSN: 0025-7931
MIYAKE, Y. ET AL.: "Pro-Gastrin-Releasing Peptide(31-98) Is a Specific Tumor Marker in Patients with Small Cell Lung Carcinoma", CANCER RESEARCH, vol. 54, 15 April 1994 (1994-04-15), pages 2136 - 2140, XP002132024
GUO Y ET AL: "PRODUCTION OF ENDOTHELINS BY THE VENTILATORY MUSCLES IN SPETIC SHOCK", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY,US,AMERICAN LUNG ASSOCIATION, NEW YORK, NY, vol. 1, no. 3, September 1998 (1998-09-01), pages 470 - 476, XP000879419, ISSN: 1044-1549
MCLOUGHLIN L ET AL: "CHARACTERIZATION OF CIRCULATING PRO-OPIOMELANCOCORTIN-RELATED PEPTIDES IN HUMAN SEPTIC SHOCK", JOURNAL OF ENDOCRINOLOGY,GB,BRISTOL, vol. 119, no. 1, October 1988 (1988-10-01), pages 159 - 165, XP000879345, ISSN: 0022-0795
NYLEN E S ET AL: "PNEUMONITIS-ASSOCIATED HYPERPROCALCITONINEMIA", AMERICAN JOURNAL OF MEDICAL SCIENCES,XX,XX, vol. 312, no. 1, July 1996 (1996-07-01), pages 12 - 18, XP000879269, ISSN: 0002-9629
ASSICOT M ET AL: "HIGH SERUM PROCALCITONIN CONCENTRATIONS IN PATIENTS WITH SEPSIS AND INFECTION", LANCET THE,GB,LANCET LIMITED. LONDON, vol. 341, no. 8844, 27 February 1993 (1993-02-27), pages 515 - 518, XP000371780, ISSN: 0140-6736
KARZAI W ET AL: "PROCALCITONIN - A NEW INDICATOR OF THE SYSTEMIC RESPONSE TO SEVERE INFECTIONS", INFECTION,DE,MMV MEDIZIN VERLAG, MUENCHEN, vol. 25, no. 6, November 1997 (1997-11-01), pages 329 - 334, XP000879253, ISSN: 0300-8126
QURESHI, N.U. ET AL.: "Endogenous neuropeptide Y mediates vasoconstriction during endotoxic and hemorrhagic shock", REGULATORY PEPTIDES, vol. 75-76, 25 September 1998 (1998-09-25), pages 215 - 220, XP000925467
NORLANDER, T. ET AL.: "Effects of experimental Mycoplasma pulmonis infection on sensory neuropeptides and airway mucosa in the rat", EUROPEAN RESPIRATORY JOURNAL, vol. 10, 1997, pages 2334 - 2342, XP000925422
KÜLLERTZ, G.: "Die Bedeutung der Aktivitätsbestimmung des Enzyms Dipeptidyl-Peptidase IV (DP IV) im klinischen Laboratorium", LAB.MED., vol. 12, 1988, pages 123 - 130, XP000933866
VANHAM, G. ET AL.: "Decreased Expression of the Memory Marker CD26 on Both CD4+ and CD8+ T Lymphocytes of HIV-Infected Subjects", JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, vol. 6, no. 7, July 1993 (1993-07-01), pages 749 - 757, XP000925435
YARON, A. AND NAIDER, F.: "Proline-Dependent Structural and Biological Properties of Peptides and Proteins", CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 28, 1993, pages 31 - 81, XP000925565
ORAVECZ T ET AL: "REGULATION OF THE RECEPTOR SPECIFICITY AND FUNCTION OF THE CHEMOKINE RANTES (REGULATED ON ACTIVATION, NORMAL T CELL EXPRESSED AND SECRETED) BY DIPEPTIDYL PEPTIDASE IV (CD26)-MEDIATED CLEAVAGE", JOURNAL OF EXPERIMENTAL MEDICINE,JP,TOKYO, vol. 186, no. 11, 1 December 1997 (1997-12-01), pages 1865 - 1872, XP002056059, ISSN: 0022-1007
P PROOST ET AL: "Amino-terminal truncation of chemokines by CD26/Dipeptidyl-peptidase IV", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 273, no. 13, 27 March 1998 (1998-03-27), pages 7222 - 7227-7227, XP002102982, ISSN: 0021-9258
WRENGER, S. ET AL: "Amino-terminal truncation of procalcitonin, a marker for systemic bacterial infections, by dipeptidyl peptidase IV (DP IV).", FEBS LETTERS, (JAN. 21, 2000) VOL. 466, NO. 1, PP. 155-159., XP002143500
NORIHARU SHIJUBO ET AL: "ELEVATED PROGASTRIN-RELEASING PEPTIDE (31-98) CONCENTRATIONS IN PLEURAL EFFUSIONS DUE TO SMALL-CELL LUNG CARCINOMA", RESPIRATION,CH,KARGER, BASEL, vol. 63, no. 2, 1 March 1996 (1996-03-01), pages 106 - 110, XP000608937, ISSN: 0025-7931
MIYAKE, Y. ET AL.: "Pro-Gastrin-Releasing Peptide(31-98) Is a Specific Tumor Marker in Patients with Small Cell Lung Carcinoma", CANCER RESEARCH, vol. 54, 15 April 1994 (1994-04-15), pages 2136 - 2140, XP002132024
GUO Y ET AL: "PRODUCTION OF ENDOTHELINS BY THE VENTILATORY MUSCLES IN SPETIC SHOCK", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY,US,AMERICAN LUNG ASSOCIATION, NEW YORK, NY, vol. 1, no. 3, September 1998 (1998-09-01), pages 470 - 476, XP000879419, ISSN: 1044-1549
MCLOUGHLIN L ET AL: "CHARACTERIZATION OF CIRCULATING PRO-OPIOMELANCOCORTIN-RELATED PEPTIDES IN HUMAN SEPTIC SHOCK", JOURNAL OF ENDOCRINOLOGY,GB,BRISTOL, vol. 119, no. 1, October 1988 (1988-10-01), pages 159 - 165, XP000879345, ISSN: 0022-0795
NYLEN E S ET AL: "PNEUMONITIS-ASSOCIATED HYPERPROCALCITONINEMIA", AMERICAN JOURNAL OF MEDICAL SCIENCES,XX,XX, vol. 312, no. 1, July 1996 (1996-07-01), pages 12 - 18, XP000879269, ISSN: 0002-9629
ASSICOT M ET AL: "HIGH SERUM PROCALCITONIN CONCENTRATIONS IN PATIENTS WITH SEPSIS AND INFECTION", LANCET THE,GB,LANCET LIMITED. LONDON, vol. 341, no. 8844, 27 February 1993 (1993-02-27), pages 515 - 518, XP000371780, ISSN: 0140-6736
KARZAI W ET AL: "PROCALCITONIN - A NEW INDICATOR OF THE SYSTEMIC RESPONSE TO SEVERE INFECTIONS", INFECTION,DE,MMV MEDIZIN VERLAG, MUENCHEN, vol. 25, no. 6, November 1997 (1997-11-01), pages 329 - 334, XP000879253, ISSN: 0300-8126
QURESHI, N.U. ET AL.: "Endogenous neuropeptide Y mediates vasoconstriction during endotoxic and hemorrhagic shock", REGULATORY PEPTIDES, vol. 75-76, 25 September 1998 (1998-09-25), pages 215 - 220, XP000925467
NORLANDER, T. ET AL.: "Effects of experimental Mycoplasma pulmonis infection on sensory neuropeptides and airway mucosa in the rat", EUROPEAN RESPIRATORY JOURNAL, vol. 10, 1997, pages 2334 - 2342, XP000925422
KÜLLERTZ, G.: "Die Bedeutung der Aktivitätsbestimmung des Enzyms Dipeptidyl-Peptidase IV (DP IV) im klinischen Laboratorium", LAB.MED., vol. 12, 1988, pages 123 - 130, XP000933866
VANHAM, G. ET AL.: "Decreased Expression of the Memory Marker CD26 on Both CD4+ and CD8+ T Lymphocytes of HIV-Infected Subjects", JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, vol. 6, no. 7, July 1993 (1993-07-01), pages 749 - 757, XP000925435
YARON, A. AND NAIDER, F.: "Proline-Dependent Structural and Biological Properties of Peptides and Proteins", CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 28, 1993, pages 31 - 81, XP000925565
ORAVECZ T ET AL: "REGULATION OF THE RECEPTOR SPECIFICITY AND FUNCTION OF THE CHEMOKINE RANTES (REGULATED ON ACTIVATION, NORMAL T CELL EXPRESSED AND SECRETED) BY DIPEPTIDYL PEPTIDASE IV (CD26)-MEDIATED CLEAVAGE", JOURNAL OF EXPERIMENTAL MEDICINE,JP,TOKYO, vol. 186, no. 11, 1 December 1997 (1997-12-01), pages 1865 - 1872, XP002056059, ISSN: 0022-1007
P PROOST ET AL: "Amino-terminal truncation of chemokines by CD26/Dipeptidyl-peptidase IV", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 273, no. 13, 27 March 1998 (1998-03-27), pages 7222 - 7227-7227, XP002102982, ISSN: 0021-9258
WRENGER, S. ET AL: "Amino-terminal truncation of procalcitonin, a marker for systemic bacterial infections, by dipeptidyl peptidase IV (DP IV).", FEBS LETTERS, (JAN. 21, 2000) VOL. 466, NO. 1, PP. 155-159., XP002143500
Download PDF:
Previous Patent: PROGNOSTIC METHOD FOR ANTI-RESORPTIVE TREATMENT
Next Patent: AUTOMATIC SEPARATOR/EXTRACTOR AND CONTROL METHOD THEREFOR
Next Patent: AUTOMATIC SEPARATOR/EXTRACTOR AND CONTROL METHOD THEREFOR