Title:
METHOD FOR SUPPORTING AMINO ACID ON RESIN FOR SOLID-PHASE SYNTHESIS
Document Type and Number:
WIPO Patent Application WO/2022/145444
Kind Code:
A1
Abstract:
A problem addressed by the present invention is to provide a method for efficiently producing a high-purity peptide compound at a high yield. It was discovered that an amino acid can be supported efficiently by a resin for solid-phase synthesis by bringing an amino acid solution including a specific solvent into contact with a resin for solid-phase synthesis swollen by a specific solvent, thereby solving the problem.
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| JPH0314597 | NOVEL ENDOSERINE DERIVATIVE |
Inventors:
SEKITA HIROKO (JP)
KOMIYA SHIO (JP)
DAN KATSUNORI (JP)
KOMIYA SHIO (JP)
DAN KATSUNORI (JP)
Application Number:
PCT/JP2021/048743
Publication Date:
July 07, 2022
Filing Date:
December 28, 2021
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K1/06; C07K7/50
Domestic Patent References:
| WO2018225851A1 | 2018-12-13 | |||
| WO2013100132A1 | 2013-07-04 | |||
| WO2018115864A1 | 2018-06-28 | |||
| WO2020122182A1 | 2020-06-18 | |||
| WO2018225851A1 | 2018-12-13 | |||
| WO2020111238A1 | 2020-06-04 | |||
| WO2018225864A1 | 2018-12-13 |
Foreign References:
| JP2013533264A | 2013-08-22 | |||
| CN102643330A | 2012-08-22 | |||
| JP2014517022A | 2014-07-17 |
Other References:
JAD YAHYA E.; ACOSTA GERARDO A.; KHATTAB SHERINE N.; TORRE BEATRIZ G. DE LA; GOVENDER THAVENDRAN; KRUGER HENDRIK G.; EL-FAHAM AYMA: "2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis", AMINO ACIDS., SPRINGER VERLAG., AU, vol. 48, no. 2, 24 September 2015 (2015-09-24), AU , pages 419 - 426, XP035889321, ISSN: 0939-4451, DOI: 10.1007/s00726-015-2095-x
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CHEM. REV., vol. 119, 2019, pages 10360 - 10391
AMINO ACIDS, PEPTIDES AND PROTEINS IN ORGANIC CHEMISTRY: BUILDING BLOCKS, CATALYSIS AND COUPLING CHEMISTRY, vol. 3, 2011
AMINO ACIDS, vol. 50, 2018, pages 39 - 68
BACHEM: "Solid phase peptide synthesis", 6 November 2020
J. PEPTIDE RES., vol. 65, 2005, pages 153 - 166
"Side reaction in peptide synthesis", vol. 6, 2015, ACADEMIC PRESS, pages: 119 - 161
BIOPOLYMERS, vol. 98, 2012, pages 89 - 97
QSAR COMB. SCI., vol. 26, 2007, pages 1027 - 1035
ACS COMB. SCI., vol. 15, 2013, pages 229 - 234
ARTICLE IN MOLECULAR BIOTECHNOLOGY, vol. 33, 2006, pages 239 - 254
JOHN WILEYSONS: "Greene's", 2014, JOHN WILEY & SONS, article "Protective Groups in Organic Synthesis"
"Solid Phase Synthesis Handbook", 1 May 2002, MERCK
J. AM. CHEM. SOC., vol. 85, 1963, pages 2149 - 2154
FUTURE MED. CHEM., vol. 1, 2009, pages 1289 - 1310
ACC. CHEM. RES., vol. 41, 2008, pages 1331 - 1342
ANGEW. CHEM. INT. ED., vol. 52, 2013, pages 254 - 269
CHEM. REV., vol. 119, 2019, pages 10360 - 10391
AMINO ACIDS, PEPTIDES AND PROTEINS IN ORGANIC CHEMISTRY: BUILDING BLOCKS, CATALYSIS AND COUPLING CHEMISTRY, vol. 3, 2011
AMINO ACIDS, vol. 50, 2018, pages 39 - 68
BACHEM: "Solid phase peptide synthesis", 6 November 2020
J. PEPTIDE RES., vol. 65, 2005, pages 153 - 166
"Side reaction in peptide synthesis", vol. 6, 2015, ACADEMIC PRESS, pages: 119 - 161
BIOPOLYMERS, vol. 98, 2012, pages 89 - 97
QSAR COMB. SCI., vol. 26, 2007, pages 1027 - 1035
ACS COMB. SCI., vol. 15, 2013, pages 229 - 234
ARTICLE IN MOLECULAR BIOTECHNOLOGY, vol. 33, 2006, pages 239 - 254
JOHN WILEYSONS: "Greene's", 2014, JOHN WILEY & SONS, article "Protective Groups in Organic Synthesis"
"Solid Phase Synthesis Handbook", 1 May 2002, MERCK
Attorney, Agent or Firm:
HASEGAWA, Yoshiki et al. (JP)
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