Title:
METHOD FOR SYNTHESIZING 17-POSITION SIDE CHAIN OF STEROID DRUG
Document Type and Number:
WIPO Patent Application WO/2019/128154
Kind Code:
A1
Abstract:
Provided is a method for synthesizing the 17-position side chain of a steroid drug, wherein same is characterized in using compound I as a starting material, and the 17-position side chain is synthesized by nucleophilic, esterification, elimination and oxidation reactions, etc. Compared with the traditional process, the method uses a cyano group on 3-hydroxypropionitrile, instead of using extremely toxic substances such as acetone cyanohydrin or sodium cyanide, such that same is safer and more environmentally friendly, wherein each step of same is relatively easy to implement, and same has a high yield, a high purity, and more economical and safer production, and is thus more suitable for industrial production.
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Inventors:
YANG KUN (CN)
YU CHUANYUN (CN)
YU CHUANYUN (CN)
Application Number:
PCT/CN2018/092378
Publication Date:
July 04, 2019
Filing Date:
June 22, 2018
Export Citation:
Assignee:
GUANGXI WONDER PHARMACEUTICAL CO LTD (CN)
International Classes:
C07J5/00; C07J1/00; C07J7/00
Foreign References:
| CN108101950A | 2018-06-01 | |||
| US4600538A | 1986-07-15 | |||
| CN106866768A | 2017-06-20 | |||
| CN104327142A | 2015-02-04 |
Attorney, Agent or Firm:
CHINA TRUER IP (CN)
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