Title:
METHOD FOR SYNTHESIZING 5-BROMO-1H-3-AMINO-1,2,4-TRIAZOLE
Document Type and Number:
WIPO Patent Application WO/2022/126388
Kind Code:
A1
Abstract:
A method for synthesizing 5-bromo-1H-3-amino-1,2,4-triazole. The method has a route as (aa), in which a mixture of sodium bromate and sodium bromide is employed to serve as a brominated reagent; and a reaction route as (bb). The synthesis of 5-bromo-1H-3-amino-1,2,4-triazole per the method has a novel process route and a total molar yield of greater than 50%. The reaction is highly safe and easy to industrialize, and has a high yield, inexpensive costs, and relatively mild reaction conditions.
Inventors:
YE WEIPING (CN)
PHILLIS ANDREW TOROA (CN)
ZHOU ZHANGTAO (CN)
XIE YANGYIN (CN)
XI LINGANG (CN)
XIANG WEI (CN)
PHILLIS ANDREW TOROA (CN)
ZHOU ZHANGTAO (CN)
XIE YANGYIN (CN)
XI LINGANG (CN)
XIANG WEI (CN)
Application Number:
PCT/CN2020/136575
Publication Date:
June 23, 2022
Filing Date:
December 15, 2020
Export Citation:
Assignee:
SHENZHEN HWAGEN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D249/08
Domestic Patent References:
WO2011010840A1 | 2011-01-27 |
Foreign References:
CN109071555A | 2018-12-21 | |||
CN103044466A | 2013-04-17 | |||
CN105153027A | 2015-12-16 |
Other References:
GAO XUEZHI, ET AL.: "Synthesis Improvement of the Key Intermediate of Lansoprazole 2,3-Dimethyl-4-(2,2,2-Trifluoroethoxy)pyridine-N-Oxide", CHINESE JOURNAL OF PHARMACEUTICALS, SHANGHAI YIYAO GONGYE YANJIUYUAN,SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, CN, vol. 49, no. 9, 31 December 2018 (2018-12-31), CN , pages 1252 - 1254, XP055942985, ISSN: 1001-8255, DOI: 10.16522/j.cnki.cjph.2018.09.007
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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