Title:
METHOD FOR SYNTHESIZING ZIRCONIUM COMPLEX
Document Type and Number:
WIPO Patent Application WO/2021/145099
Kind Code:
A1
Abstract:
The objective of the present invention is to synthesize a zirconium complex by making even a low concentration of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) react with radioactive zirconium at a high reaction rate. A mixed solution, obtained by finally mixing zirconium dissolved in an acidic solution into a solution in which a solution containing 40-95 vol% of an organic substance having water miscibility is mixed with a compound containing a chelating agent represented by DOTA, etc., is heated to a prescribed temperature of 35°C or higher to thereby synthesize a zirconium complex. The acidic solution is a hydrochloric acid, and the organic substance is methanol or ethanol.
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Inventors:
IMURA RYOTA (JP)
Application Number:
PCT/JP2020/045605
Publication Date:
July 22, 2021
Filing Date:
December 08, 2020
Export Citation:
Assignee:
JFE ENG CORP (JP)
International Classes:
C07D255/02; C07D257/02; C07F7/00; C22B3/44; C22B34/14
Domestic Patent References:
| WO2017161356A1 | 2017-09-21 |
Foreign References:
| JP2018123372A | 2018-08-09 | |||
| JP2018123372A | 2018-08-09 |
Other References:
PANDYA DARPAN N., HENRY KELLY E., DAY CYNTHIA S., GRAVES STEPHEN A., NAGLE VERONICA L., DILLING THOMAS R., SINHA AKESH, EHRMANN BR: "Polyazamacrocycle Ligands Facilitate 89Zr Radiochemistry and Yield 89Zr Complexes with Remarkable Stability.", INORGANIC CHEMISTRY, vol. 59, no. 23, 10 November 2020 (2020-11-10), pages 17473 - 17487, XP055843521, DOI: 10.1021/acs. inorgchem.0c02722
"Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development", CHEM. SCI., vol. 8, 2017, pages 2309 - 2314
"Evaluation of a chloride-based 89Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin", NUCL. BIO. AND MED., vol. 64, 2018, pages 1 - 7
See also references of EP 4092016A4
"Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development", CHEM. SCI., vol. 8, 2017, pages 2309 - 2314
"Evaluation of a chloride-based 89Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin", NUCL. BIO. AND MED., vol. 64, 2018, pages 1 - 7
See also references of EP 4092016A4
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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