Title:
METHOD AND SYSTEM FOR IDENTIFICATION OF CANDIDATE TARGET SITES FOR COMBATING PATHOGENS
Document Type and Number:
WIPO Patent Application WO/2020/245785
Kind Code:
A3
Abstract:
A system and method for identification of target sites in a pathogenic genome and combating a pathogenic infection have been provided. The present disclosure utilizes the fact that a conserved stretch of nucleotide sequence in genomic neighborhood of genes important for bacteria can be targeted to disrupt the overall functioning of the pathogen. The method involves identification of nucleotide repeat sequences in the DNA. The method and system also involves administration of a cocktail comprising antimicrobial drugs, biofilm inhibitors and a construct. The genomic neighborhood or vicinity or 'flanking genes' refers to regions lying within a predefined number of genes to the identified conserved stretch of nucleotide repeat sequence (or its reverse complement) on the candidate pathogen genome or within a distance of predefined number of bases with respect to the conserved stretch of nucleotide repeat sequence (or its reverse complement) on the candidate pathogen genome.
Inventors:
MANDE SHARMILA SHEKHAR (IN)
ANAND SWADHA (IN)
SAMPATH PREETHI ALAGARAI (IN)
ANAND SWADHA (IN)
SAMPATH PREETHI ALAGARAI (IN)
Application Number:
PCT/IB2020/055312
Publication Date:
May 06, 2021
Filing Date:
June 05, 2020
Export Citation:
Assignee:
TATA CONSULTANCY SERVICES LTD (IN)
International Classes:
A23L33/135; A61K9/00; C07F9/38; C12Q1/689
Domestic Patent References:
| WO2019005866A1 | 2019-01-03 |
Foreign References:
| US20120165215A1 | 2012-06-28 | |||
| US20140045744A1 | 2014-02-13 | |||
| US20180032668A1 | 2018-02-01 |
Other References:
CROUCHER NICHOLAS J; VERNIKOS GEORGIOS S; PARKHILL JULIAN; BENTLEY STEPHEN D: "Identification, variation and transcription of pneumococcal repeat sequences", BMC GENOMICS, vol. 12, no. 120, 18 February 2011 (2011-02-18), pages 1 - 13, XP021086412, DOI: 10.1186/1471-2164-12-120
Attorney, Agent or Firm:
KHAITAN & CO (IN)
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