Title:
METHOD FOR TESTING FOR SENSITIVITY OF CHEMOTHERAPY AGAINST COLORECTAL CANCER
Document Type and Number:
WIPO Patent Application WO/2020/241770
Kind Code:
A1
Abstract:
A method for testing for the sensitivity of a chemotherapy against colorectal cancer, in which the occurrence of methylation in at least one site selected from the group consisting of CpG sites in regions (i) to (xvi) in DNA collected from a colorectal cancer patient is employed as an indicator (wherein the regions (i) to (xvi) are as mentioned in the description).
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Inventors:
ISHIOKA CHIKASHI (JP)
TAKAHASHI SHIN (JP)
OUCHI KOUTA (JP)
OKITA AKIRA (JP)
SAITO TATSURO (JP)
NAKAMURA JUNKO (JP)
TSUYADA AKIHIRO (JP)
TAKAHASHI SHIN (JP)
OUCHI KOUTA (JP)
OKITA AKIRA (JP)
SAITO TATSURO (JP)
NAKAMURA JUNKO (JP)
TSUYADA AKIHIRO (JP)
Application Number:
PCT/JP2020/021173
Publication Date:
December 03, 2020
Filing Date:
May 28, 2020
Export Citation:
Assignee:
UNIV TOHOKU (JP)
RIKEN GENESIS CO LTD (JP)
RIKEN GENESIS CO LTD (JP)
International Classes:
C12Q1/68; C12Q1/686; C12Q1/6869; C12Q1/6872; C12Q1/6886; G01N33/53; A61K39/395; A61P1/04; A61P35/00
Domestic Patent References:
| WO2016060278A1 | 2016-04-21 | |||
| WO2013033627A2 | 2013-03-07 | |||
| WO2016060278A1 | 2016-04-21 |
Other References:
KOTA OUCHI, SHIN TAKAHASHI , YASUHIDE YAMADA , SHINGO TSUJI , KENJI TATSUNO , HIDEKAZU TAKAHASHI , NAOKI TAKAHASHI , MASANOBU TAK: "DNA methylation status as a biomarker of anti-epidermal growth factor receptor treatment for metastatic colorectal cancer", CANCER SCIENCE, vol. 106, no. 12, December 2015 (2015-12-01), pages 1722 - 1729, XP055766699
KIM, J.C. ET AL.: "Genome-wide identification of possible methylation markers chemosensitive to targeted regimens in colorectal cancers", J. CANCER RES. CLIN. ONCOL., vol. 137, 18 August 2011 (2011-08-18), pages 1571 - 1580, XP019951977, DOI: 10.1007/s00432-011-1036-7
SAMBROOK, J.: "Molecular Cloning: A Laboratory Manual", 1998, COLDSPRINGHARBORLABORATORY PRESS
KIM, J.C. ET AL.: "Genome-wide identification of possible methylation markers chemosensitive to targeted regimens in colorectal cancers", J. CANCER RES. CLIN. ONCOL., vol. 137, 18 August 2011 (2011-08-18), pages 1571 - 1580, XP019951977, DOI: 10.1007/s00432-011-1036-7
SAMBROOK, J.: "Molecular Cloning: A Laboratory Manual", 1998, COLDSPRINGHARBORLABORATORY PRESS
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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