Title:
METHODS AND COMPOSITION FOR ISOPRENOID DIPHOSPHATE SYNTHESIS
Document Type and Number:
WIPO Patent Application WO/2011/009132
Kind Code:
A3
Abstract:
Provided herein are methods and compositions relating to the synthesis of isoprenoid diphosphates using a mutated isopentenyl phosphate kinase.
Inventors:
NOEL JOSEPH P (US)
DELLAS NIKKI M (US)
DELLAS NIKKI M (US)
Application Number:
PCT/US2010/042472
Publication Date:
May 26, 2011
Filing Date:
July 19, 2010
Export Citation:
Assignee:
SALK INST FOR BIOLOGICAL STUDI (US)
NOEL JOSEPH P (US)
DELLAS NIKKI M (US)
NOEL JOSEPH P (US)
DELLAS NIKKI M (US)
International Classes:
C12N9/12; C12N15/54; C12P9/00; G01N33/58
Other References:
GROCHOWSKI, L. L. ET AL.: "Methanocaldococcus jannaschii uses a modified meva lonate pathway for biosynthesis of isopentenyl diphosphate", JOURNAL OF BACTERIOLOGY., vol. 188, no. 9, May 2006 (2006-05-01), pages 3192 - 3198
SCHRAMM, A. M. ET AL.: "Backbone flexibility, conformational change, and cata lysis in a phosphohexomutase from Pseudomonas aeruginasa", BIOCHEMISTRY, vol. 47, no. 35, 9 August 2008 (2008-08-09), pages 9154 - 9162
UDA, K. ET AL.: "The role of Arg-96 in Danio rerio creatine kinase in substra te recognition and active center configuration", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES., vol. 44, no. 5, 14 March 2009 (2009-03-14), pages 413 - 418, XP026090111, DOI: doi:10.1016/j.ijbiomac.2009.03.001
TIEDGE, M. ET AL.: "Importance of cysteine residues for the stability and cat alytic activity of human pancreatic beta cell glucokinase", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS., vol. 375, no. 2, 15 March 2000 (2000-03-15), pages 251 - 260
DELLAS, N. ET AL.: "Mutation of archaeal isopentenyl phosphate kinas e highlights mechanism and guides phosphorylation of additional isoprenoid m onophosphates", ACS CHEMICAL BIOLOGY., vol. 5, no. 6, 18 June 2010 (2010-06-18), pages 589 - 601
SCHRAMM, A. M. ET AL.: "Backbone flexibility, conformational change, and cata lysis in a phosphohexomutase from Pseudomonas aeruginasa", BIOCHEMISTRY, vol. 47, no. 35, 9 August 2008 (2008-08-09), pages 9154 - 9162
UDA, K. ET AL.: "The role of Arg-96 in Danio rerio creatine kinase in substra te recognition and active center configuration", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES., vol. 44, no. 5, 14 March 2009 (2009-03-14), pages 413 - 418, XP026090111, DOI: doi:10.1016/j.ijbiomac.2009.03.001
TIEDGE, M. ET AL.: "Importance of cysteine residues for the stability and cat alytic activity of human pancreatic beta cell glucokinase", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS., vol. 375, no. 2, 15 March 2000 (2000-03-15), pages 251 - 260
DELLAS, N. ET AL.: "Mutation of archaeal isopentenyl phosphate kinas e highlights mechanism and guides phosphorylation of additional isoprenoid m onophosphates", ACS CHEMICAL BIOLOGY., vol. 5, no. 6, 18 June 2010 (2010-06-18), pages 589 - 601
Attorney, Agent or Firm:
KOERBER, Steven, C. et al. (Two Embarcadero Center8th Floo, San Francisco California, US)
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