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Title:
METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION
Document Type and Number:
WIPO Patent Application WO/2022/078350
Kind Code:
A1
Abstract:
Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

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Inventors:
YING WEIWEN (US)
FOLEY KEVIN PAUL (US)
YIN WEI (CN)
YE LONG (CN)
WANG MINGKAI (CN)
YING CHENGHAO (CN)
ZHANG LINGJIE (CN)
Application Number:
PCT/CN2021/123366
Publication Date:
April 21, 2022
Filing Date:
October 12, 2021
Export Citation:
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Assignee:
RANOK THERAPEUTICS HANGZHOU CO LTD (CN)
International Classes:
A61K31/55; C07D487/04; A61P35/00; C07D401/14; C07D403/04; C07D403/14; C07D513/04
Domestic Patent References:
WO2021061894A12021-04-01
WO2016105518A12016-06-30
WO2017007612A12017-01-12
WO2017024317A22017-02-09
WO2018148440A12018-08-16
WO2014145909A22014-09-18
WO2014160430A12014-10-02
Foreign References:
US20190151457A12019-05-23
US20190315753A12019-10-17
US20170008888A12017-01-12
Other References:
FERGUSON FLEUR M., LIU YAN, HARSHBARGER WAYNE, HUANG LING, WANG JINHUA, DENG XIANMING, CAPUZZI STEPHEN J., MURATOV EUGENE N., TROP: "Synthesis and Structure–Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6 H -benzo[ e ]pyrimido[5,4- b ][1,4]diazepin-6-one Scaffold", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 14, 23 July 2020 (2020-07-23), US , pages 7817 - 7826, XP055921966, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00596
WANG JINHUA, ERAZO TATIANA, FERGUSON FLEUR M., BUCKLEY DENNIS L., GOMEZ NESTOR, MUÑOZ-GUARDIOLA PAU, DIÉGUEZ-MARTÍNEZ NORA, DENG X: "Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains", ACS CHEMICAL BIOLOGY, vol. 13, no. 9, 21 September 2018 (2018-09-21), pages 2438 - 2448, XP055921970, ISSN: 1554-8929, DOI: 10.1021/acschembio.7b00638
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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