Title:
METHODS AND COMPOSITIONS FOR THE TREATMENT OF WOUNDS
Document Type and Number:
WIPO Patent Application WO/2019/094938
Kind Code:
A3
Abstract:
The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.
Inventors:
HUBBELL JEFFREY A (US)
RANDI ANNA M (GB)
ISHIHARA JUN (US)
ISHIHARA AKO (US)
BRIQUEZ PRISCILLA (US)
STARKE RICHARD (GB)
RANDI ANNA M (GB)
ISHIHARA JUN (US)
ISHIHARA AKO (US)
BRIQUEZ PRISCILLA (US)
STARKE RICHARD (GB)
Application Number:
PCT/US2018/060760
Publication Date:
June 27, 2019
Filing Date:
November 13, 2018
Export Citation:
Assignee:
UNIV CHICAGO (US)
IMP INNOVATIONS (GB)
IMP INNOVATIONS (GB)
International Classes:
C07K4/00; C07K4/12
Foreign References:
| US20080233125A1 | 2008-09-25 |
Other References:
JUN ISHIHARA ET AL: "Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing", NATURE COMMUNICATIONS, vol. 9, no. 1, 4 June 2018 (2018-06-04), XP055568823, DOI: 10.1038/s41467-018-04525-w
"Micro- and Nanoengineering of the Cell Surface", 1 January 2014, ELSEVIER, ISBN: 978-1-4557-3146-6, article MANIRAJ BHAGAWATI ET AL: "Biofunctionalization of Hydrogels for Engineering the Cellular Microenvironment", pages: 315 - 348, XP055568583, DOI: 10.1016/B978-1-4557-3146-6.00014-3
MIKAÃ
LAURA DE LAPORTE ET AL: "Tenascin C Promiscuously Binds Growth Factors via Its Fifth Fibronectin Type III-Like Domain", PLOS ONE, vol. 8, no. 4, 18 April 2013 (2013-04-18), pages e62076, XP055568815, DOI: 10.1371/journal.pone.0062076
M. M. MARTINO ET AL: "Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, no. 12, 4 March 2013 (2013-03-04), US, pages 4563 - 4568, XP055372533, ISSN: 0027-8424, DOI: 10.1073/pnas.1221602110
SCHENSE J C ET AL: "CROSS-LINKING EXOGENOUS BIFUNCTIONAL PEPTIDES INTO FIBRIN GELS WITHFACTOR XIIIA", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 1, 1 January 1999 (1999-01-01), pages 75 - 81, XP000867031, ISSN: 1043-1802, DOI: 10.1021/BC9800769
"Micro- and Nanoengineering of the Cell Surface", 1 January 2014, ELSEVIER, ISBN: 978-1-4557-3146-6, article MANIRAJ BHAGAWATI ET AL: "Biofunctionalization of Hydrogels for Engineering the Cellular Microenvironment", pages: 315 - 348, XP055568583, DOI: 10.1016/B978-1-4557-3146-6.00014-3
MIKAÃ
LAURA DE LAPORTE ET AL: "Tenascin C Promiscuously Binds Growth Factors via Its Fifth Fibronectin Type III-Like Domain", PLOS ONE, vol. 8, no. 4, 18 April 2013 (2013-04-18), pages e62076, XP055568815, DOI: 10.1371/journal.pone.0062076
M. M. MARTINO ET AL: "Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, no. 12, 4 March 2013 (2013-03-04), US, pages 4563 - 4568, XP055372533, ISSN: 0027-8424, DOI: 10.1073/pnas.1221602110
SCHENSE J C ET AL: "CROSS-LINKING EXOGENOUS BIFUNCTIONAL PEPTIDES INTO FIBRIN GELS WITHFACTOR XIIIA", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 1, 1 January 1999 (1999-01-01), pages 75 - 81, XP000867031, ISSN: 1043-1802, DOI: 10.1021/BC9800769
Attorney, Agent or Firm:
STELLMAN, Laurie Friesenhahn (US)
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