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Patent Searching and Data


Title:
METHODS AND DEVICE FOR THE ANALYSIS OF TISSUE SAMPLES
Document Type and Number:
WIPO Patent Application WO/2021/110799
Kind Code:
A3
Abstract:
The present invention relates to methods, and devices to analyze the phenotype and/or genotype of cells obtained from tissue samples. In particular, the present invention relates to the analysis of the response of the cells as obtained to the exposure of a drug compound or combinations thereof. The methods of the present invention offer the particular advantage of being time-effective, and suitable for automatization.

Inventors:
KELM JENS (CH)
STEINER PETER (CH)
Application Number:
PCT/EP2020/084383
Publication Date:
July 29, 2021
Filing Date:
December 03, 2020
Export Citation:
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Assignee:
PRECOMB THERAPEUTICS AG (CH)
International Classes:
G01N33/50; A61L2/00; B01L1/00; G01N35/00; G21F7/005
Foreign References:
US20110024419A12011-02-03
Other References:
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M JEPPESEN ET AL: "Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine", PLOS ONE, vol. 12, no. 9, E0183074, 6 September 2017 (2017-09-06), XP055781150, DOI: 10.1371/journal.pone.0183074
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ANONYMOUS: "Cell Biology - Compound Screening - Cell Based Compound Screening System", TECAN: CUSTOMIZED SOLUTIONS FROM TIG, 1 January 2010 (2010-01-01), pages 1 - 5, XP055781841, Retrieved from the Internet [retrieved on 20210303]
A A POPOVA ET AL: "Facile One Step Formation and Screening of Tumor Spheroids Using Droplet-Microarray Platform", SMALL, vol. 15, 1901299, 6 May 2019 (2019-05-06), XP055780741, Retrieved from the Internet DOI: 10.1002/smll.201901299
G HAMILTON ET AL: "Applicability of tumor spheroids for in vitro chemosensitivity assays", EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, vol. 15, no. 1, 2 December 2018 (2018-12-02), pages 15 - 23, XP055781153, Retrieved from the Internet DOI: 10.1080/17425255.2019.1554055
S A LANGHANS: "Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning", FRONTIERS IN PHARMACOLOGY, vol. 9, 6, 23 January 2018 (2018-01-23), XP055664722, DOI: 10.3389/fphar.2018.00006
Y FANG ET AL: "Three-Dimensional Cell Cultures in Drug Discovery and Development", SOCIETY FOR LABORATORY AUTOMATION AND SCREENING DISCOVERY, vol. 22, no. 5, 1 January 2017 (2017-01-01), pages 456 - 472, XP055652687
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Attorney, Agent or Firm:
BOEHMERT & BOEHMERT ANWALTSPARTNERSCHAFT MBB (DE)
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