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Patent Searching and Data


Title:
METHODS FOR EXTENDING LIFESPAN AND METHODS OF SCREENING KNOWN PHARMACOLOGICAL AGENTS FOR NEW USES
Document Type and Number:
WIPO Patent Application WO/2016/168670
Kind Code:
A3
Abstract:
The present disclosure relates to methods of extending the lifespan of a subject or treating, suppressing, inhibiting or delaying the onset of an age-related condition or disorder, such as cancer, in a subject. The methods comprise administering to the subject an effective amount of (i) a compound that sustains pharmacological activation of xenobiotic metabolism, (ii) a cardiac glycoside, (iii) a chelator, (iv) inulin, (v) D-valine, or any combination thereof. In a further aspect, the present disclosure relates to a method of identifying clinical candidates by performing a high throughput screening in mammals of test compounds which have great structural and/or functional diversity.

Inventors:
RYAZANOV ALEXEY G (US)
CHIKUNOV ALEXANDER V (US)
SHYMKIV YURIY (US)
Application Number:
PCT/US2016/027859
Publication Date:
December 01, 2016
Filing Date:
April 15, 2016
Export Citation:
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Assignee:
LONGEVICA THERAPEUTICS INC (US)
International Classes:
A61K31/37; A61P39/00; C07D311/02
Foreign References:
US20120003335A12012-01-05
Other References:
STEINBAUGH ET AL.: "Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan.", AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, vol. 303, no. 4, 2012, pages E488 - 95, XP055332162
Attorney, Agent or Firm:
LESSLER, Jay, P. (The Chrysler Building405 Lexington Ave, New York NY, US)
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