Title:
METHODS FOR PREPARING ANTIBODIES WITH A DEFINED GLYCOSYLATION PATTERN
Document Type and Number:
WIPO Patent Application WO/2017/132298
Kind Code:
A8
Abstract:
The present disclosure relates to a process for preparing antibodies with a defined glycosylation pattern, in particular antibodies with a glycan terminating in an N-acetylglucosamine. The antibodies of the disclosure are suitable for use in a process to conjugate a payload thereto. The disclosure also extends to molecules obtained and obtainable from the process disclosed herein, novel molecules and intermediates, compositions comprising said molecules and uses of the molecules and compositions, particularly in treatment, for example in the treatment of cancer.
Inventors:
GAO CHANGSHOU (US)
THOMPSON PAMELA (US)
TOADER DORIN (US)
DIMASI NAZZARENO (US)
THOMPSON PAMELA (US)
TOADER DORIN (US)
DIMASI NAZZARENO (US)
Application Number:
PCT/US2017/015005
Publication Date:
July 12, 2018
Filing Date:
January 26, 2017
Export Citation:
Assignee:
MEDIMMUNE LLC (US)
International Classes:
A61K39/395; C07K16/00; C12P21/00
Attorney, Agent or Firm:
GALVEZ, Jason, J. et al. (US)
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