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Title:
METHYLATION BIOMARKERS FOR PREDICTING RELAPSE FREE SURVIVAL
Document Type and Number:
WIPO Patent Application WO/2010/073218
Kind Code:
A3
Abstract:
A methylation classification list comprising loci DNA, for which loci the methylation status of the DNA is indicative of likelihood of recurrence of cancer, is provided. Furthermore, a method, apparatus and use for predicting probability of relapse free survival of a subject diagnosed with cancer, are provided.

Inventors:
KAMALAKARAN SITHARTHAN (US)
VARADAN VINAY (US)
HICKS JAMES B (US)
Application Number:
PCT/IB2009/055909
Publication Date:
October 14, 2010
Filing Date:
December 22, 2009
Export Citation:
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Assignee:
KONINKL PHILIPS ELECTRONICS NV (NL)
COLD SPRING HARBOR LAB
KAMALAKARAN SITHARTHAN (US)
VARADAN VINAY (US)
HICKS JAMES B (US)
International Classes:
C12Q1/68
Domestic Patent References:
WO2002077272A22002-10-03
Foreign References:
EP1840224A12007-10-03
EP1612281A22006-01-04
Other References:
BROCK MALCOLM V ET AL: "DNA methylation markers and early recurrence in stage I lung cancer.", THE NEW ENGLAND JOURNAL OF MEDICINE 13 MAR 2008, vol. 358, no. 11, 13 March 2008 (2008-03-13), pages 1118 - 1128, XP002575979, ISSN: 1533-4406
CUSTODIO ANA BEL√ČN ET AL: "Prognostic and predictive markers of benefit from adjuvant chemotherapy in early-stage non-small cell lung cancer.", JOURNAL OF THORACIC ONCOLOGY : OFFICIAL PUBLICATION OF THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER JUL 2009, vol. 4, no. 7, July 2009 (2009-07-01), pages 891 - 910, XP009131531, ISSN: 1556-1380
Attorney, Agent or Firm:
KROEZE, John et al. (Building 44, AE Eindhoven, NL)
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