Title:
MICRO-FLUIDIC CHIP PRINTING NOZZLE AND BIOLOGICAL 3D PRINTING SYSTEM
Document Type and Number:
WIPO Patent Application WO/2021/012534
Kind Code:
A1
Abstract:
A micro-fluidic chip nozzle, comprising a micro-fluidic chip and a nozzle having a double-layer structure. The micro-fluidic chip comprises a micro-fluidic chip substrate layer and a micro-fluidic chip upper layer; a plurality of flow channels and mixed-flow-structured flow channels are formed on the micro-fluidic chip substrate layer, and the mixed-flow-structured flow channels are connected to a micro-fluidic chip outlet; micro valves corresponding to the plurality of flow channels are formed on the micro-fluidic chip upper layer, and the micro valves can be controlled to be opened or closed so as to control liquid of the different flow channels to enter the mixed-flow-structured flow channels; the nozzle having a double-layer structure comprises an inner-layer micro needle head and a housing, the inner-layer micro needle head is connected to the micro-fluidic chip outlet, the housing is provided with a cross-linking liquid inlet and a nozzle outlet; a mixed solution fed from the inner-layer micro needle head and cross-linking liquid fed from the cross-linking liquid inlet are mixed in the housing and are cross-linked to produce gel fibers, and the gel fibers flow out from the nozzle outlet. The micro-fluidic chip nozzle structure of the present invention is particularly suitable for printing a gradient tissue engineering cornea having a layered structure.
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Inventors:
MI SHENGLI (CN)
SUN WEI (CN)
KE XIN (CN)
SUN WEI (CN)
KE XIN (CN)
Application Number:
PCT/CN2019/118877
Publication Date:
January 28, 2021
Filing Date:
November 15, 2019
Export Citation:
Assignee:
TSINGHUA SHENZHEN INT GRADUATE SCHOOL (CN)
International Classes:
C12M1/36; A61F2/00; B33Y30/00; C12M3/00
Foreign References:
| CN107937270A | 2018-04-20 | |||
| CN107937270A | 2018-04-20 | |||
| CN107106734A | 2017-08-29 | |||
| CN110257243A | 2019-09-20 | |||
| CN109822898A | 2019-05-31 | |||
| CN104441654A | 2015-03-25 | |||
| CN103587119A | 2014-02-19 |
Attorney, Agent or Firm:
CHINA TRUER IP (CN)
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