Title:
MICROCIN MCCY, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/156055
Kind Code:
A1
Abstract:
Provided is the microcin MccY, wherein the amino acid sequence of the microcin is GGRGHIAEYFSGPITQVAFYG. Further provided are a method for preparing the microcin and the use thereof. Compared with MccJ25 which only has bactericidal activity on a small part of serotype salmonella such as enteritis, the small rhizomorph MccY has a bacteriostatic/bactericidal effect on Salmonella pullorum, Salmonella typhimurium, Salmonella kentucky, Salmonella infantis, Salmonella London and Shigella sonnei, and can kill other salmonella serotypes which cannot be killed by MccJ25; in particular, the small rhizomorph MccY has a remarkable bactericidal effect on Salmonella typhimurium and Salmonella pullorum which are common in livestock and poultry production, also has a bacteriostatic/bactericidal effect on Shigella sonnei, thereby overcoming the shortcoming of the small rhizomorph having a narrow spectrum.
Inventors:
CAO WEISHENG (CN)
LI YU (CN)
FENG SAIXIANG (CN)
LI YU (CN)
FENG SAIXIANG (CN)
Application Number:
PCT/CN2021/081398
Publication Date:
July 28, 2022
Filing Date:
March 18, 2021
Export Citation:
Assignee:
UNIV SOUTH CHINA AGRICULT (CN)
International Classes:
C07K14/195; A23K20/147; A61K38/16; A61P31/04; C12N1/21; C12N15/31; C12N15/70; C12R1/19
Domestic Patent References:
| WO2012146729A1 | 2012-11-01 |
Foreign References:
| CN106317210A | 2017-01-11 | |||
| CN110343709A | 2019-10-18 | |||
| CN110172415A | 2019-08-27 | |||
| CN103717744A | 2014-04-09 |
Other References:
DATABASE PROTEIN 20 February 2019 (2019-02-20), ANONYMOUS : "acinetodin/klebsidin/J25 family lasso peptide [Salmonella enterica subsp. enterica] ", XP055952811, retrieved from NCBI Database accession no. EAB749503
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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