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Patent Searching and Data


Title:
MICROFLUIDIC SYSTEM SIMULATING LUNG TISSUE
Document Type and Number:
WIPO Patent Application WO/2021/066537
Kind Code:
A1
Abstract:
Disclosed are a biomimic system simulating lung tissue, a method for manufacturing same, and a microfluidic control method using same, wherein the biomimic system comprises lung epithelial cells and lung fibroblasts, which are isolated from human lungs, and commercially available vascular endothelial cells, and wherein a microfluid flows through the biomimic system. Each chamber inside the corresponding system can allow a fluid, which contains gas and a medium, to flow therethrough and simulate respiration-like movement, wherein all of the three types of cells can survive inside the system even when one week or more have elapsed after through-flow of the fluid. In addition, the pH and pO2 in the chamber can be monitored by using a pH sensor and a gas partial pressure sensor inside the system, and thus the three types of cells inside the system can be exposed to external environments, drugs, and the like under the same conditions as in the lungs in vivo. Therefore, a wide range of studies including modeling of lung diseases by harmful substances and testing of therapeutic drug efficacy can be conducted, and further, the utilization to in vitro disease modeling, customized medicine prescriptions, and the like can also be made.

Inventors:
CHO YOUNG-JAE (KR)
PARK MI-YOUNG (KR)
EO EUN YOUNG (KR)
Application Number:
PCT/KR2020/013365
Publication Date:
April 08, 2021
Filing Date:
September 29, 2020
Export Citation:
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Assignee:
SEOUL NAT UNIV HOSPITAL (KR)
International Classes:
C12M3/06; C12M1/00; C12M1/12; C12M1/34; C12N5/071
Foreign References:
JP2018531603A2018-11-01
JP2018038425A2018-03-15
KR20190088711A2019-07-29
US20140335496A12014-11-13
US20140308688A12014-10-16
Other References:
WILLIAM ZACHARIAS , EDWARD MORRISEY: "Isolation and culture of human alveolar epithelial progenitor cells", pages 1 - 9, XP055796982, Retrieved from the Internet DOI: 10.1038/protex.2018.015
Attorney, Agent or Firm:
CHOI, Woo-sung (KR)
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