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Patent Searching and Data


Title:
MICROMOLECULAR PCSK9 PROTEIN DEGRADATION AGENT, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/165373
Kind Code:
A1
Abstract:
Provided are a micromolecular PCSK9 protein degradation agent and a preparation method therefor. The micromolecular PCSK9 inhibitor is a tetrahydroisoquinoline compound having a chemical structure represented by formula (I), or a pharmaceutically acceptable salt or solvate thereof. The compound has the effect of degrading PCSK9 or degrading LC3, and can be used in preparing a medicament for preventing or treating a PCSK9 or LC3 activity-related disease.

Inventors:
GU XIANFENG (CN)
OUYANG ZHIRONG (CN)
GUO WEI (CN)
MA MUYE (CN)
Application Number:
PCT/CN2023/077334
Publication Date:
September 07, 2023
Filing Date:
February 21, 2023
Export Citation:
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Assignee:
UNIV FUDAN (CN)
International Classes:
C07D417/14; A61K31/404; A61K31/47; A61P3/00; A61P35/00; C07D209/04; C07D209/34; C07D217/00; C07D217/12; C07D417/12
Foreign References:
US20200369657A12020-11-26
CN105777633A2016-07-20
US20190119236A12019-04-25
Attorney, Agent or Firm:
HANQIAO PATENT et al. (CN)
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