Title:
MICROORGANISMS AND PROCESSES FOR PRODUCING TEREPHTHALIC ACID AND ITS SALTS
Document Type and Number:
WIPO Patent Application WO/2013/109865
Kind Code:
A3
Abstract:
The invention provides non-naturally occurring microbial organisms having a (2- hydroxy-3-methyl-4-oxobutoxy) phosphonate (2H3M40P) pathway, p-toluate pathway, and/or terephthalate pathway. The invention additionally provides methods of using such organisms to produce 2H3M40P, p-toluate or terephthalate. Also provided herein are processes for isolating bio-based aromatic carboxylic acid, in particular, p-toluic acid or terephthalic acid, from a culture medium, wherein the processes involve contacting the culture medium with sufficient carbon dioxide (C02) to lower the pH of the culture medium to produce a precipitate comprised of the aromatic carboxylic acid.
Inventors:
OSTERHOUT ROBIN E (US)
BURGARD ANTHONY P (US)
BURK MARK J (US)
BURGARD ANTHONY P (US)
BURK MARK J (US)
Application Number:
PCT/US2013/022113
Publication Date:
September 12, 2013
Filing Date:
January 18, 2013
Export Citation:
Assignee:
GENOMATICA INC (US)
International Classes:
C12N9/02; C07C63/04; C07C63/26; C07F9/09; C08G63/183; C08L67/02; C12N9/04; C12N9/10; C12N9/12; C12N9/88; C12P7/24; C12P7/40; C12P7/44; C12P9/00
Domestic Patent References:
| WO2011094131A1 | 2011-08-04 | |||
| WO2011017560A1 | 2011-02-10 | |||
| WO2009120457A2 | 2009-10-01 |
Other References:
PANG ET AL: "Review of conventional and novel polymerization processes for polyesters", PROGRESS IN POLYMER SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 31, no. 11, 15 November 2006 (2006-11-15), pages 1009 - 1037, XP005728579, ISSN: 0079-6700, DOI: 10.1016/J.PROGPOLYMSCI.2006.08.008
EKATERINA A SAVRASOVA ET AL: "Use of the valine biosynthetic pathway to convert glucose into isobutanol", JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY ; OFFICIAL JOURNAL OF THE SOCIETY FOR INDUSTRIAL MICROBIOLOGY, SPRINGER, BERLIN, DE, vol. 38, no. 9, 15 December 2010 (2010-12-15), pages 1287 - 1294, XP019943556, ISSN: 1476-5535, DOI: 10.1007/S10295-010-0907-2
EKATERINA A SAVRASOVA ET AL: "Use of the valine biosynthetic pathway to convert glucose into isobutanol", JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY ; OFFICIAL JOURNAL OF THE SOCIETY FOR INDUSTRIAL MICROBIOLOGY, SPRINGER, BERLIN, DE, vol. 38, no. 9, 15 December 2010 (2010-12-15), pages 1287 - 1294, XP019943556, ISSN: 1476-5535, DOI: 10.1007/S10295-010-0907-2
Attorney, Agent or Firm:
FRIEBEL, Thomas E. et al. (222 East 41st StreetNew York, NY, US)
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