Title:
MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/202511
Kind Code:
A3
Abstract:
The disclosure relates to double stranded ribonucleic acid interference (dsRNAi) agents and compositions targeting a microtubule-associated protein tau (MAPT) gene, as well as methods of inhibiting expression of a MAPT gene and methods of treating subjects having a MAPT-associated disease or disorder, e.g., Alzheimer's disease, frontotemporal dementia, progressive supranuclear palsy, or other tauopathies, using such dsRNAi agents and compositions.
Inventors:
SOUNDARAPANDIAN MANGALA MEENAKSHI (US)
MCININCH JAMES D (US)
FISHILEVICH ELANE (US)
CASTORENO ADAM (US)
KAITTANIS CHARALAMBOS (US)
SCHLEGEL MARK K (US)
FARLEY JONATHAN EDWARD (US)
ZUBER JEFFREY (US)
MCININCH JAMES D (US)
FISHILEVICH ELANE (US)
CASTORENO ADAM (US)
KAITTANIS CHARALAMBOS (US)
SCHLEGEL MARK K (US)
FARLEY JONATHAN EDWARD (US)
ZUBER JEFFREY (US)
Application Number:
PCT/US2021/024858
Publication Date:
November 25, 2021
Filing Date:
March 30, 2021
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS INC (US)
International Classes:
A61P25/16; A61P25/28; C12N15/113
Foreign References:
| US20150275205A1 | 2015-10-01 | |||
| US20170175116A1 | 2017-06-22 |
Attorney, Agent or Firm:
MEIGS, Julie Broadus et al. (US)
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