Title:
MINI-PROMOTER PCALM1 AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/283749
Kind Code:
A1
Abstract:
A mini-promoter pCALM1 and an application thereof are provided. The promoter is a partial sequence of the human calmodulin 1 gene, a core promoter region sequence from -80 to +40 of a transcription initiation site of the CALM1 gene, a total of 120 bp, being selected in this sequence; the nucleotide sequence information thereof being as shown in SEQ ID NO.1. It can be used in recombinant adeno-associated virus so that exogenous genes can be expressed in neurons in the whole brain, and can be used in the fields of gene editing and gene therapy.
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Inventors:
LU ZHONGHUA (CN)
LIN JIANBANG (CN)
LI TIAN (CN)
LIN JIANBANG (CN)
LI TIAN (CN)
Application Number:
PCT/CN2021/101456
Publication Date:
January 19, 2023
Filing Date:
July 13, 2021
Export Citation:
Assignee:
SHENZHEN ENJI BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N15/113; A61K48/00; A61K49/00; A61P25/00; C12N15/65; C12N15/864
Foreign References:
| CN112680443A | 2021-04-20 | |||
| CN112725342A | 2021-04-30 |
Other References:
DATABASE NUCLEOTIDE ANONYMOUS : "Homo sapiens Sharpr-MPRA regulatory region 5900 (LOC112272566) on chromosome 14 ", XP093024358, retrieved from NCBI
SHI DONGQUAN; NI HAIJIAN; DAI JIN; QIN JIANGHUI; XU YONG; ZHU LUNQING; YAO CHEN; SHAO ZHENXING; CHEN DONGYANG; XU ZHIHONG; YI LONG: "Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population", BMC MEDICAL GENETICS, BIOMED CENTRAL, LONDON, GB, vol. 9, no. 1, 22 October 2008 (2008-10-22), GB , pages 91, XP021042802, ISSN: 1471-2350, DOI: 10.1186/1471-2350-9-91
SHI DONGQUAN; NI HAIJIAN; DAI JIN; QIN JIANGHUI; XU YONG; ZHU LUNQING; YAO CHEN; SHAO ZHENXING; CHEN DONGYANG; XU ZHIHONG; YI LONG: "Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population", BMC MEDICAL GENETICS, BIOMED CENTRAL, LONDON, GB, vol. 9, no. 1, 22 October 2008 (2008-10-22), GB , pages 91, XP021042802, ISSN: 1471-2350, DOI: 10.1186/1471-2350-9-91
Attorney, Agent or Firm:
GUANGZHOU KEWOYUAN PATENT AGENCY CO., LTD. (CN)
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