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Patent Searching and Data


Title:
MITHRAMYCIN DERIVATIVES HAVING INCREASED SELECTIVITY AND ANTI-CANCER ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2020/106357
Kind Code:
A3
Abstract:
Mithramycin (MTM) short side chain ketone (SK) derivatives and MTM short side chain diketone (SDK) derivatives are provided. The MTM SK and MTM SDK derivatives are useful for treatment of cancer or neuro-diseases associated with an aberrant erythroblast transformation-specific transcription factor. Unique MTM SK and MTM SDK derivatives have increased selectively toward ETS transcription factor.

Inventors:
ROHR JURGEN (US)
TSODIKOV OLEG (US)
LEGGAS MARKOS (US)
HOU CAIXI (US)
ECKENRODE JOSEPH (US)
MITRA PRITHIBA (US)
MANDAL ABHISEK (US)
Application Number:
PCT/US2019/052118
Publication Date:
July 02, 2020
Filing Date:
September 20, 2019
Export Citation:
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Assignee:
UNIV KENTUCKY RES FOUND (US)
International Classes:
C07H15/24; A61K31/7034; A61K31/704
Foreign References:
US9447135B22016-09-20
US8592379B22013-11-26
Other References:
MITRA ET AL.: "Development of Mithramycin Analogues with Increased Selectivity toward ETS Transcription Factor Expressing Cancers", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, 16 August 2018 (2018-08-16), pages 8001 - 8016, XP055723038
WEIDENBACH ET AL.: "Dimerization and DNA recognition rules of mithramycin and its analogues", J INORG BIOCHEM., vol. 156, 2016, pages 40 - 47, XP029411433, DOI: 10.1016/j.jinorgbio.2015.12.011
Attorney, Agent or Firm:
DECKER, Mandy Wilson et al. (US)
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