Title:
MODEL OF HUMAN NON-ALCOHOLIC STEATOHEPATITIS
Document Type and Number:
WIPO Patent Application WO/2019/088208
Kind Code:
A1
Abstract:
A model of human non-alcoholic steatohepatitis which comprises an animal obtained by feeding a chimeric rodent, in which hepatocytes have been partially or totally substituted by human hepatocytes, with an adjusted feed having one or more characteristics selected from among: (a) the content of choline or a salt thereof being 0.01 wt% or less relative to the total amount of the adjusted feed; (b) the content of methionine being 0.5 wt% or less relative to the total amount of the adjusted feed; and (c) the fat content being 25 kcal% or more relative to the total calorie value of proteins, carbohydrates and fats contained in the adjusted feed. This model stably exhibits the symptoms of human non-alcoholic steatohepatitis.
Inventors:
SUGAHARA GO (JP)
KISOH KEISHI (JP)
ISHIDA YUJI (JP)
MUKAIDANI CHISE (JP)
KOHARA MICHINORI (JP)
KISOH KEISHI (JP)
ISHIDA YUJI (JP)
MUKAIDANI CHISE (JP)
KOHARA MICHINORI (JP)
Application Number:
PCT/JP2018/040601
Publication Date:
May 09, 2019
Filing Date:
October 31, 2018
Export Citation:
Assignee:
PHOENIXBIO CO LTD (JP)
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
International Classes:
C12N15/01; A01K67/027; G01N33/15; G01N33/50
Domestic Patent References:
| WO2008001614A1 | 2008-01-03 | |||
| WO2015170694A1 | 2015-11-12 | |||
| WO2013015331A1 | 2013-01-31 |
Foreign References:
| JP2012080830A | 2012-04-26 | |||
| JP2006349457A | 2006-12-28 |
Other References:
MINICS, SAMUELE DE ET AL.: "Role and Cellular Source of Nicotinamide Adenine Dinucleotide Phosphate Oxidase in Hepatic Fibrosis", HEPATOLOGY, vol. 52, 2010, pages 1420 - 1430, XP55612265
Attorney, Agent or Firm:
TADA Eiko et al. (JP)
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