Title:
MODIFIED NUCLEOSIDE, NUCLEOTIDE AND MODIFIED NUCLEIC ACID POLYMER, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/000380
Kind Code:
A1
Abstract:
The present disclosure relates to the technical field of nucleic acid medicines, in particular to a modified nucleoside, a nucleotide and a modified nucleic acid polymer, as well as a preparation method therefor and an application thereof. The modified nucleoside is selected from a compound having the following structure or a salt thereof: formula (1). According to the modified nucleoside of the present disclosure, an azido group, an amino group or an amine group and the like are introduced at a 4' position by means of modifying the nucleoside, and a novel modified nucleoside structure is obtained. The modified nucleoside may be further modified to obtain the nucleotide and the modified nucleic acid polymer, and has good ribozyme tolerance.
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Inventors:
WANG SHENGQI (CN)
HE XIAOYANG (CN)
YANG JING (CN)
REN JIN (CN)
DAI YU (CN)
DENG XINXIU (CN)
LU DANDAN (CN)
HE XIAOYANG (CN)
YANG JING (CN)
REN JIN (CN)
DAI YU (CN)
DENG XINXIU (CN)
LU DANDAN (CN)
Application Number:
PCT/CN2019/100641
Publication Date:
January 07, 2021
Filing Date:
August 14, 2019
Export Citation:
Assignee:
ACAD OF MILITARY MEDICAL SCIENCES (CN)
International Classes:
C07H19/067; C07H1/00; C07H19/10; C07H19/167; C07H19/20; C12N15/11; C12Q1/6876
Domestic Patent References:
| WO2015106128A2 | 2015-07-16 |
Other References:
MALEK-ADAMIAN, ELISE ET AL.: "Adjusting the Structure of 2'-Modified Nucleosides and Oligonucleotides via C4'-α-F or C4'-α-OMe Substitution: Synthesis and Conformational Analysis.", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 83, 2 July 2018 (2018-07-02), XP055771369, DOI: 20200316091701A
MALEK-ADAMIAN, ELISE ET AL.: "4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, 22 September 2017 (2017-09-22), XP055771373, DOI: 20200316092556A
LIBOSKA, RADEK ET AL.: "4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics.", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, 5 September 2011 (2011-09-05), XP055164995, DOI: 20200316092842A
MALEK-ADAMIAN, ELISE ET AL.: "4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, 22 September 2017 (2017-09-22), XP055771373, DOI: 20200316092556A
LIBOSKA, RADEK ET AL.: "4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics.", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, 5 September 2011 (2011-09-05), XP055164995, DOI: 20200316092842A
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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