Title:
MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION
Document Type and Number:
WIPO Patent Application WO2002032920
Kind Code:
A3
Abstract:
The disclosed invention is a composition for and a method of treating a Flaviviridae (including BVDV and HCV), Orthomyxoviridae (including Influenza A and B) or Paramyxoviridae (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside of general formula (I)-(XXIII) or its pharmaceutically acceptable salt or prodrug. This invention also provides an effective process to quantify the viral load, and in particular BVDV, HCV or West Nile Virus load, in a host, using real-time polymerase chain reaction ("TR-PCR"). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample.
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Inventors:
STUYVER LIEVEN (US)
WATANABE KYOICHI A (US)
WATANABE KYOICHI A (US)
Application Number:
PCT/US2001/046113
Publication Date:
February 19, 2004
Filing Date:
October 18, 2001
Export Citation:
Assignee:
PHARMASSET LTD (BB)
STUYVER LIEVEN (US)
WATANABE KYOICHI A (US)
STUYVER LIEVEN (US)
WATANABE KYOICHI A (US)
International Classes:
C07D473/18; A61K31/513; A61K31/52; A61K31/522; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61P3/12; A61P31/12; A61P35/00; A61P35/02; C07D405/04; C07D473/30; C07D473/34; C07H19/048; C07H19/06; C07H19/067; C07H19/10; C07H19/16; C07H19/167; C07H19/20; C07H21/04; C12Q1/68; (IPC1-7): A61K31/706; A61K31/7064; A61K31/7068; A61K31/7076; A61P31/12; A61P35/00
Domestic Patent References:
| WO1998018324A1 | 1998-05-07 | |||
| WO2001060315A2 | 2001-08-23 | |||
| WO2002018404A2 | 2002-03-07 |
Other References:
DATABASE WPI Section Ch Week 198631, Derwent World Patents Index; Class B03, AN 1986-199712, XP002232023
LIN, TAI SHUN ET AL: "Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogs, and crystal structure of 1-(3-deoxy-.beta.-D-threo- pentofuranosyl)cytosine", JOURNAL OF MEDICINAL CHEMISTRY (1991), 34(2), 693-701, XP001109492
LOCKSHIN, ARNOLD ET AL: "Selective cytotoxicity of 5-hydroxyuridine for human colon adenocarcinoma cells", CANCER TREATMENT REPORTS (1985), 69(7-8), 845-9, XP008012570
DOLLINGER, MALIN R. ET AL: "Analogs of 1-.beta.-D-arabinofuranosylcytosine. Studies on mechamisms of action in Burkitt's cell culture and mouse leukemia, and in vitro deamination studies", BIOCHEMICAL PHARMACOLOGY (1967), 16(4), 689-706, XP008012573
HOSHINO, JIRO ET AL: "Suppression of nuclear ADP-ribosyltransferase activity in Ehrlich ascites tumor cells by 5-azacytidine and its analogs", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1987), 142(2), 468-7, XP001109488
LIN, TAI SHUN ET AL: "Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogs, and crystal structure of 1-(3-deoxy-.beta.-D-threo- pentofuranosyl)cytosine", JOURNAL OF MEDICINAL CHEMISTRY (1991), 34(2), 693-701, XP001109492
LOCKSHIN, ARNOLD ET AL: "Selective cytotoxicity of 5-hydroxyuridine for human colon adenocarcinoma cells", CANCER TREATMENT REPORTS (1985), 69(7-8), 845-9, XP008012570
DOLLINGER, MALIN R. ET AL: "Analogs of 1-.beta.-D-arabinofuranosylcytosine. Studies on mechamisms of action in Burkitt's cell culture and mouse leukemia, and in vitro deamination studies", BIOCHEMICAL PHARMACOLOGY (1967), 16(4), 689-706, XP008012573
HOSHINO, JIRO ET AL: "Suppression of nuclear ADP-ribosyltransferase activity in Ehrlich ascites tumor cells by 5-azacytidine and its analogs", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1987), 142(2), 468-7, XP001109488
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