Title:
MODIFIED OLIGONUCLEOTIDES AND COMPOUND THAT CAN BE USED FOR SYNTHESIZING SAME
Document Type and Number:
WIPO Patent Application WO/2019/127004
Kind Code:
A1
Abstract:
The present invention falls within the field of biomedical technology, and in particular relates to modified oligonucleotides and a compound that can be used for synthesizing same, and a method for modifying oligonucleotides. The present invention also relates to the use of the modified oligonucleotides for preventing and/or treating diseases associated with the liver in a subject.
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Inventors:
ZHANG BILIANG (CN)
WANG WEI (CN)
YE YIDONG (CN)
WANG WEI (CN)
YE YIDONG (CN)
Application Number:
PCT/CN2017/118591
Publication Date:
July 04, 2019
Filing Date:
December 26, 2017
Export Citation:
Assignee:
GUANGZHOU RIBOBIO CO LTD (CN)
International Classes:
C07H21/00; A61K31/7028; A61P1/16; C07H1/00; C07H15/04
Domestic Patent References:
| WO2016028649A1 | 2016-02-25 | |||
| WO2013089522A1 | 2013-06-20 |
Foreign References:
| CN106795200A | 2017-05-31 | |||
| CN106589042A | 2017-04-26 | |||
| CN106471010A | 2017-03-01 | |||
| US20150119444A1 | 2015-04-30 | |||
| US20150119445A1 | 2015-04-30 | |||
| US20150126718A1 | 2015-05-07 | |||
| US20140046425W | 2014-07-11 |
Other References:
LOBST S T ET AL., J BIOL CHEM, vol. 271, no. 12, 1996, pages 6686 - 6693
LEE Y C ET AL., J BIOL CHEM, vol. 258, no. 1, 1983, pages 199 - 202
PRAKASH, T. P. ET AL., NUCLEIC ACIDS RES., vol. 42, pages 8796 - 807
LEE ET AL., CARBOHYDRATES IN CHEMISTRY AND BIOLOGY, vol. 4, 2000, pages 549
CHOI J YBORCH R F: "Highly efficient synthesis of enantiomerically enriched 2-hydroxymethylaziridines by enzymatic desymmetrization.[J", ORGANIC LETTERS, vol. 9, no. 2, 2007, pages 215 - 218
HUDSON, C.S .JOHNSON, J. J., AM. CHEM. SOC., vol. 37, 1915, pages 1270 - 1275
See also references of EP 3677588A4
LEE Y C ET AL., J BIOL CHEM, vol. 258, no. 1, 1983, pages 199 - 202
PRAKASH, T. P. ET AL., NUCLEIC ACIDS RES., vol. 42, pages 8796 - 807
LEE ET AL., CARBOHYDRATES IN CHEMISTRY AND BIOLOGY, vol. 4, 2000, pages 549
CHOI J YBORCH R F: "Highly efficient synthesis of enantiomerically enriched 2-hydroxymethylaziridines by enzymatic desymmetrization.[J", ORGANIC LETTERS, vol. 9, no. 2, 2007, pages 215 - 218
HUDSON, C.S .JOHNSON, J. J., AM. CHEM. SOC., vol. 37, 1915, pages 1270 - 1275
See also references of EP 3677588A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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