Title:
RORγT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143771
Kind Code:
A1
Abstract:
Provided are an RORγt modulator, and a preparation method therefor and an application thereof. The RORγt modulator is selected from a compound represented by formula I, and a pharmaceutically acceptable salt, solvate, solvate of the pharmaceutically acceptable salt, metabolite, or prodrug thereof. The compound has inhibitory activity on RORγt, and can effectively inhibit an RORγt protein receptor, thereby regulating differentiation of Th17 cells, inhibiting generation of IL-17, and then treating RORγt-mediated relevant autoimmune diseases.
Inventors:
WANG QIAN (CN)
ZHANG BINGBIN (CN)
XIA GUANGXIN (CN)
SHU SIJIE (CN)
HUO GUOYONG (CN)
XIANG ZHIJUN (CN)
WU GUOSHENG (CN)
LIANG TAO (CN)
SHI CHEN (CN)
ZHAO YONGXIN (CN)
LI LINGWEN (CN)
KE YING (CN)
ZHANG BINGBIN (CN)
XIA GUANGXIN (CN)
SHU SIJIE (CN)
HUO GUOYONG (CN)
XIANG ZHIJUN (CN)
WU GUOSHENG (CN)
LIANG TAO (CN)
SHI CHEN (CN)
ZHAO YONGXIN (CN)
LI LINGWEN (CN)
KE YING (CN)
Application Number:
PCT/CN2021/142477
Publication Date:
July 07, 2022
Filing Date:
December 29, 2021
Export Citation:
Assignee:
SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)
International Classes:
C07D213/75; A61K31/44; A61K31/4402; A61K31/4427; A61K31/4439; A61K31/505; A61K31/506; A61P1/00; A61P11/00; A61P17/06; A61P25/00; A61P29/00; A61P37/00; C07D213/84; C07D239/04; C07D401/06; C07D405/06; C07D417/06
Domestic Patent References:
| WO2015101928A1 | 2015-07-09 | |||
| WO2014179564A1 | 2014-11-06 | |||
| WO2015083130A1 | 2015-06-11 | |||
| WO2016193459A1 | 2016-12-08 | |||
| WO2017010399A1 | 2017-01-19 |
Foreign References:
| CN101827840A | 2010-09-08 |
Other References:
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
"Handbook of Pharmaceutical Salts", 2002, WILEY-VCH
"Pharmacopoeia of the People's Republic of China", vol. 4, 2015
RAYMOND C ROWE: "Handbook of Pharmaceutical Excipients", 2009
"Handbook of Pharmaceutical Salts", 2002, WILEY-VCH
"Pharmacopoeia of the People's Republic of China", vol. 4, 2015
RAYMOND C ROWE: "Handbook of Pharmaceutical Excipients", 2009
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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