MODULATORS OF MELANOCORTIN RECEPTOR

Title:

MODULATORS OF MELANOCORTIN RECEPTOR

Document Type and Number:

WIPO Patent Application WO2004050610

Kind Code:

A3

Abstract:

This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by formula I: wherein X is oxygen or sulfur; G is G1 or G2: L1, L2, L3 and Q are linker groups, and Rings A, B and C, and R<1>-R<14> are described in the specification. The compounds are antagonists of melanocortin receptors.

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Inventors:

VOS TRICIA J (US)
PATANE MICHAEL (US)
SOLOMON MICHAEL E (US)
BLACKBURN CHRISTOPHER (US)
DANCA MIHAELA D (US)

Application Number:

PCT/US2003/038369

Publication Date:

August 26, 2004

Filing Date:

December 04, 2003

Export Citation:

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Assignee:

MILLENNIUM PHARM INC (US)
VOS TRICIA J (US)
PATANE MICHAEL (US)
SOLOMON MICHAEL E (US)
BLACKBURN CHRISTOPHER (US)
DANCA MIHAELA D (US)

International Classes:

A61P3/00; C07D207/12; C07D207/14; C07D207/16; C07D207/22; C07D209/14; C07D211/26; C07D211/34; C07D211/60; C07D211/62; C07D213/40; C07D217/02; C07D233/88; C07D239/16; C07D239/42; C07D295/13; C07D295/185; C07D307/79; C07D333/20; C07D333/38; C07D401/06; C07D407/12; C07D409/12; C07D451/04; C07D453/02; C07D471/10; C07D521/00; (IPC1-7): C07D295/12; A61K31/44; A61P3/00; C07C279/22; C07D213/40; C07D333/20; C07D333/38; C07D409/12; C07D239/16; C07D233/88; C07D239/42; C07D207/16; C07D295/18; C07D453/02; C07D307/79

Domestic Patent References:

WO2001064639A2	2001-09-07
WO2000027819A2	2000-05-18
WO2002062766A2	2002-08-15
WO2001010842A2	2001-02-15

Foreign References:

EP0810205A1	1997-12-03
EP0676395A2	1995-10-11
EP1219609A1	2002-07-03

Other References:

RIED ET AL: "Synthesis of new potentially analgesic and antibiotic pyridazino[4,3-e][1,3]oxazinones and pyrimido[4,5-c]pyridazinones", ARCHIV DER PHARMAZIE (WEINHEIM, GERMANY) , 321(9), 527-32, 1988, XP002142201
VIGNE P ET AL: "STRUCTURE ACTIVITY RELATIONSHIPS OF AMILORIDE AND CERTAIN OF ITS ANALOGS IN RELATION TO THE BLOCKADE OF THE SODIUM HYDROGEN EXCHANGE SYSTEM", MOLECULAR PHARMACOLOGY, vol. 25, no. 1, 1984, pages 131 - 136, XP009031591, ISSN: 0026-895X

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