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Patent Searching and Data


Title:
MODULATORS OF RAS GTPASE
Document Type and Number:
WIPO Patent Application WO/2020/033413
Kind Code:
A3
Abstract:
RAS modulating compounds and methods of using the same are provided. The compounds find use in modulating the activity of a target RAS in a sample. The target RAS can be a mutant RAS that is implicated in a disease of interest. In some cases, the subject compounds can inhibit the growth of cancer cells whose progression is driven by kRAS or a mutated kRAS. Methods of treating a subject for a RAS driven disease including administering a therapeutically effective amount of the subject compound are provided. Also provided are pharmaceutical compositions and kits which include the subject compounds.

Inventors:
LENNEK ANNIE L (US)
YANOFSKY STEPHEN D (US)
FRENZEL BRIAN D (US)
UNGASHE SOLOMON B (US)
GARLAND WILLIAM A (US)
LIAW PHILIP (US)
Application Number:
PCT/US2019/045315
Publication Date:
May 07, 2020
Filing Date:
August 06, 2019
Export Citation:
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Assignee:
TOSK INC (US)
International Classes:
A61P35/00; C07D271/10; C07D403/12; C07D413/12
Domestic Patent References:
WO2005012256A12005-02-10
WO2017023133A22017-02-09
Foreign References:
US20180086752A12018-03-29
Other References:
DATABASE Chemical Abstract 21 March 2011 (2011-03-21), retrieved from STN Database accession no. 1269064-16-5
DATABASE Chemical Abstract 7 August 2017 (2017-08-07), retrieved from STN Database accession no. 2109536-59-4
DATABASE Chemical Abstract 7 March 2012 (2012-03-07), retrieved from STN Database accession no. 1360253-07-1
Attorney, Agent or Firm:
FIELD, Bret E. (US)
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