Title:
MOLECULE SPECIFICALLY BINDING TO CLDN18.2
Document Type and Number:
WIPO Patent Application WO/2022/111425
Kind Code:
A1
Abstract:
Provided are a molecule specifically binding to CLDN18.2, the molecule comprising an immunoglobulin single variable domain, a nucleic acid molecule encoding the molecule specifically binding to CLDN18.2, and an expression vector and a host cell for expressing the molecule specifically binding to CLDN18.2; further provided are a method for producing the molecule specifically binding to CLDN18.2 and use thereof for treating or preventing conditions associated with CLDN18.2.
Inventors:
TAN YONGCONG (CN)
LANG GUOJUN (CN)
LIU CHANJUAN (CN)
YAN XINTIAN (CN)
LANG GUOJUN (CN)
LIU CHANJUAN (CN)
YAN XINTIAN (CN)
Application Number:
PCT/CN2021/132218
Publication Date:
June 02, 2022
Filing Date:
November 23, 2021
Export Citation:
Assignee:
SANYOU BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07K16/18; A61K39/395; A61P35/00; C12N15/13; G01N33/574
Domestic Patent References:
| WO2003048731A2 | 2003-06-12 | |||
| WO1994004678A1 | 1994-03-03 | |||
| WO1990003430A1 | 1990-04-05 | |||
| WO1987000195A1 | 1987-01-15 |
Foreign References:
| CN112480248A | 2021-03-12 | |||
| EP2852408A1 | 2015-04-01 | |||
| CN107667118A | 2018-02-06 | |||
| CN111961135A | 2020-11-20 | |||
| CN109762067A | 2019-05-17 | |||
| CN111836644A | 2020-10-27 | |||
| CN111848809A | 2020-10-30 | |||
| CN111518214A | 2020-08-11 | |||
| CN111867630A | 2020-10-30 | |||
| CN202011332200A | 2020-11-24 | |||
| US5500362A | 1996-03-19 | |||
| US5821337A | 1998-10-13 | |||
| US4399216A | 1983-08-16 | |||
| US4634665A | 1987-01-06 | |||
| US5179017A | 1993-01-12 | |||
| EP0402226A1 | 1990-12-12 | |||
| EP0183070A2 | 1986-06-04 | |||
| EP0244234A2 | 1987-11-04 | |||
| US4767704A | 1988-08-30 | |||
| US4657866A | 1987-04-14 | |||
| US4927762A | 1990-05-22 | |||
| US4560655A | 1985-12-24 | |||
| US5122469A | 1992-06-16 | |||
| USRE30985E | 1982-06-29 | |||
| US20180127489A1 | 2018-05-10 | |||
| DD120403A5 | 1976-06-12 |
Other References:
STEFAN WÖLL; ANNA MELISSA SCHLITTER; KARL DHAENE; MARC ROLLER; IRENE ESPOSITO; UGUR SAHIN; ÖZLEM TÜRECI: "Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms", INTERNATIONAL JOURNAL OF CANCER, vol. 134, no. 3, 20 November 2013 (2013-11-20), US , pages 731 - 739, XP071288537, ISSN: 0020-7136, DOI: 10.1002/ijc.28400
XU, LIANG'E ET AL.: "Advances of CLDN18.2 Protein in the Therapy of Malignant Tumors", CHINESE JOURNAL OF CLINICAL ONCOLOGY, vol. 46, no. 6, 30 March 2019 (2019-03-30), pages 311 - 315, XP009528623
HAMERS-CASTERMAN CATARHOUCH TMUYLDERMANS SROBINSON GHAMERS CSONGA EBBENDAHMAN NHAMERS R: "Naturally occurring antibodies devoid of light chains", NATURE, vol. 363, no. 6428, 1993, pages 446 - 448, XP002535892, DOI: 10.1038/363446a0
ABBAS ET AL.: "Cellular and Molecular Immunology", 2010, W.B. SAUNDERS COMPANY
KAUFMAN, R.J., MOL. BIOTECHNOL., vol. 16, 2000, pages 151 - 160
AUSUBEL ET AL.: "Short Protocols in Molecular Biology: A Compendium of Methods from Current Protocols in Molecular Biology", 2002, WILEY, JOHN & SONS, INC.
FFERNER, R. G., DRUG RES., vol. 48, 1998, pages 870 - 880
COLIGAN ET AL.: "Short Protocols in Protein Science", 2003, WILEY, JOHN & SONS, INC.
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877 - 883
GEISSE, S. ET AL., PROTEIN EXPR. PURIF., vol. 66, 1996, pages 271 - 282
MAKRIDES, S.C., PROTEIN EXPR. PURIF., vol. 17, 1999, pages 183 - 202
CARILLO ET AL., SIAMJ. APPLIED MATH., vol. 48, 1988, pages 1073
KELLEYO' CONNELL, BIOCHEM., vol. 32, 1993, pages 6862 - 1187
BARBAS ET AL., PROC. NAT. ACAD. SCI. USA, vol. 91, 1994, pages 3809 - 3813
VON HEINJE G.: "Sequences of Proteins of Immunological Interest", 1987, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
BARBAS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 7978 - 7982
GRAHAM ET AL., VIROLOGY, vol. 52, 1973, pages 456
SAMBROOK ET AL., MOLECULAR CLONING: A LABORATORY MANUAL, 2001
DAVIS ET AL.: "Basic Methods in Molecular Biology", 1986, ELSEVIER
CHU ET AL., GENE, vol. 13, 1981, pages 197
FLOWMETRIC, SORTING OUT FLUORESCENCE ACTIVATED CELL SORTING, 9 November 2017 (2017-11-09)
SCIER ET AL., GENE, vol. 169, 1995, pages 147 - 155
CARTER ET AL., BIO/TECHNOLOGY, vol. 10, 1992, pages 163 - 167
HAWKINS ET AL., J. MOL. BIOL., vol. 226, 1992, pages 889 - 896
WESOLOWSKI ET AL.: "Single Domain Antibodies: Promising Experimental and Therapeutic Tools in Infection and Immunity", MED MICROBIOL IMMUNOL, vol. 198, 2009, pages 157 - 174
R. VAN DER LINDEN ET AL., JOURNAL OF IMMUNOLOGICAL METHODS, vol. 240, 2000, pages 185 - 195
LI ET AL., J BIOL CHEM., vol. 287, 2012, pages 13713 - 13721
DEFFAR ET AL., AFRICAN JOURNAL OF BIOTECHNOLOGY, vol. 8, no. 12, 17 June 2009 (2009-06-17), pages 2645
RAVETCHKINET, ANNU. REV. IMMUNOL, vol. 9, 1991, pages 457 - 92
CLYNES ET AL., PNAS (USA, vol. 95, 1998, pages 652 - 656
GAZZANO-SANTORO ET AL., J. IMMUNOL. METHODS, vol. 202, 1996, pages 163
AL-LAZIKANI ET AL.: "Standard Conformations for the Canonical Structures of Immunoglobulins", JOURNAL OF MOLECULAR BIOLOGY, vol. 273, 1997, pages 927 - 948, XP004461383, DOI: 10.1006/jmbi.1997.1354
"Antibody Engineering", 2001, SPRINGER
BEERS ET AL., CLIN. CAN. RES., vol. 6, 2000, pages 2835 - 43
RETTER ET AL., NUCL. ACIDS RES., vol. 33, 2005, pages D671 - D674
DR. ANDREW C. R. MARTIN: "Antibody Engineering Lab Manual", SPRINGER-VERLAG, article "Protein Sequence and Structure Analysis of Antibody Variable Domains"
E. MEYERSW. MILLER, COMPUT. APPL. BIOSCI., vol. 4, 1988, pages 11 - 17
J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, no. 17, 1997, pages 3389 - 3402
KOBAYASHI ET AL., PROTEIN ENG., vol. 12, no. 10, 1999, pages 879 - 884
BURKS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 412 - 417
BRUMMELL ET AL., BIOCHEM, vol. 32, 1993, pages 1180 - 8
WILDT ET AL., PROT. ENG., vol. 10, 1997, pages 835 - 41
KOMISSAROV ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 26864 - 26870
HALL ET AL., J. IMMUNOL., vol. 149, 1992, pages 1605 - 12
ADIB-CONQUY ET AL., INT. IMMUNOL., vol. 10, 1998, pages 341 - 6
HAM ET AL., METH. ENZ., vol. 58, 1979, pages 44
BARNES ET AL., ANAL. BIOCHEM., vol. 102, 1980, pages 255
XU, LIANG'E ET AL.: "Advances of CLDN18.2 Protein in the Therapy of Malignant Tumors", CHINESE JOURNAL OF CLINICAL ONCOLOGY, vol. 46, no. 6, 30 March 2019 (2019-03-30), pages 311 - 315, XP009528623
HAMERS-CASTERMAN CATARHOUCH TMUYLDERMANS SROBINSON GHAMERS CSONGA EBBENDAHMAN NHAMERS R: "Naturally occurring antibodies devoid of light chains", NATURE, vol. 363, no. 6428, 1993, pages 446 - 448, XP002535892, DOI: 10.1038/363446a0
ABBAS ET AL.: "Cellular and Molecular Immunology", 2010, W.B. SAUNDERS COMPANY
KAUFMAN, R.J., MOL. BIOTECHNOL., vol. 16, 2000, pages 151 - 160
AUSUBEL ET AL.: "Short Protocols in Molecular Biology: A Compendium of Methods from Current Protocols in Molecular Biology", 2002, WILEY, JOHN & SONS, INC.
FFERNER, R. G., DRUG RES., vol. 48, 1998, pages 870 - 880
COLIGAN ET AL.: "Short Protocols in Protein Science", 2003, WILEY, JOHN & SONS, INC.
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877 - 883
GEISSE, S. ET AL., PROTEIN EXPR. PURIF., vol. 66, 1996, pages 271 - 282
MAKRIDES, S.C., PROTEIN EXPR. PURIF., vol. 17, 1999, pages 183 - 202
CARILLO ET AL., SIAMJ. APPLIED MATH., vol. 48, 1988, pages 1073
KELLEYO' CONNELL, BIOCHEM., vol. 32, 1993, pages 6862 - 1187
BARBAS ET AL., PROC. NAT. ACAD. SCI. USA, vol. 91, 1994, pages 3809 - 3813
VON HEINJE G.: "Sequences of Proteins of Immunological Interest", 1987, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
BARBAS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 7978 - 7982
GRAHAM ET AL., VIROLOGY, vol. 52, 1973, pages 456
SAMBROOK ET AL., MOLECULAR CLONING: A LABORATORY MANUAL, 2001
DAVIS ET AL.: "Basic Methods in Molecular Biology", 1986, ELSEVIER
CHU ET AL., GENE, vol. 13, 1981, pages 197
FLOWMETRIC, SORTING OUT FLUORESCENCE ACTIVATED CELL SORTING, 9 November 2017 (2017-11-09)
SCIER ET AL., GENE, vol. 169, 1995, pages 147 - 155
CARTER ET AL., BIO/TECHNOLOGY, vol. 10, 1992, pages 163 - 167
HAWKINS ET AL., J. MOL. BIOL., vol. 226, 1992, pages 889 - 896
WESOLOWSKI ET AL.: "Single Domain Antibodies: Promising Experimental and Therapeutic Tools in Infection and Immunity", MED MICROBIOL IMMUNOL, vol. 198, 2009, pages 157 - 174
R. VAN DER LINDEN ET AL., JOURNAL OF IMMUNOLOGICAL METHODS, vol. 240, 2000, pages 185 - 195
LI ET AL., J BIOL CHEM., vol. 287, 2012, pages 13713 - 13721
DEFFAR ET AL., AFRICAN JOURNAL OF BIOTECHNOLOGY, vol. 8, no. 12, 17 June 2009 (2009-06-17), pages 2645
RAVETCHKINET, ANNU. REV. IMMUNOL, vol. 9, 1991, pages 457 - 92
CLYNES ET AL., PNAS (USA, vol. 95, 1998, pages 652 - 656
GAZZANO-SANTORO ET AL., J. IMMUNOL. METHODS, vol. 202, 1996, pages 163
AL-LAZIKANI ET AL.: "Standard Conformations for the Canonical Structures of Immunoglobulins", JOURNAL OF MOLECULAR BIOLOGY, vol. 273, 1997, pages 927 - 948, XP004461383, DOI: 10.1006/jmbi.1997.1354
"Antibody Engineering", 2001, SPRINGER
BEERS ET AL., CLIN. CAN. RES., vol. 6, 2000, pages 2835 - 43
RETTER ET AL., NUCL. ACIDS RES., vol. 33, 2005, pages D671 - D674
DR. ANDREW C. R. MARTIN: "Antibody Engineering Lab Manual", SPRINGER-VERLAG, article "Protein Sequence and Structure Analysis of Antibody Variable Domains"
E. MEYERSW. MILLER, COMPUT. APPL. BIOSCI., vol. 4, 1988, pages 11 - 17
J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, no. 17, 1997, pages 3389 - 3402
KOBAYASHI ET AL., PROTEIN ENG., vol. 12, no. 10, 1999, pages 879 - 884
BURKS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 412 - 417
BRUMMELL ET AL., BIOCHEM, vol. 32, 1993, pages 1180 - 8
WILDT ET AL., PROT. ENG., vol. 10, 1997, pages 835 - 41
KOMISSAROV ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 26864 - 26870
HALL ET AL., J. IMMUNOL., vol. 149, 1992, pages 1605 - 12
ADIB-CONQUY ET AL., INT. IMMUNOL., vol. 10, 1998, pages 341 - 6
HAM ET AL., METH. ENZ., vol. 58, 1979, pages 44
BARNES ET AL., ANAL. BIOCHEM., vol. 102, 1980, pages 255
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
Download PDF: