Title:
MONO- OR POLYENIC CARBOXYLIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1996/013478
Kind Code:
A1
Abstract:
Novel retinoid-related compounds that can substitute for retinoic acid as preventives or remedies for various diseases and compounds that are antagonistic to retinoids, i.e., heterocyclic compounds represented by the general formula (1-I): Z-(CR3=CR2)n-COOR1 or physiologically acceptable salts thereof, and compounds represented by general formula (2-I) or physiologically acceptable salts thereof. The compounds have a potent ability to combine with RARs and are efficacious in treating various diseases including various keratinization anomalies and rheumatoid arthritis.
Inventors:
HIBI SHIGEKI (JP)
KIKUCHI KOUICHI (JP)
YOSHIMURA HIROYUKI (JP)
NAGAI MITSUO (JP)
TAGAMI KATSUYA (JP)
ABE SHINYA (JP)
HISHINUMA IEHARU (JP)
NAGAKAWA JUNICHI (JP)
MIYAMOTO NORIMASA (JP)
HIDA TAKAYUKI (JP)
OGASAWARA AICHI (JP)
HIGASHI SEIKO (JP)
TAI KENJI (JP)
YAMANAKA TAKASHI (JP)
ASADA MAKOTO (JP)
KIKUCHI KOUICHI (JP)
YOSHIMURA HIROYUKI (JP)
NAGAI MITSUO (JP)
TAGAMI KATSUYA (JP)
ABE SHINYA (JP)
HISHINUMA IEHARU (JP)
NAGAKAWA JUNICHI (JP)
MIYAMOTO NORIMASA (JP)
HIDA TAKAYUKI (JP)
OGASAWARA AICHI (JP)
HIGASHI SEIKO (JP)
TAI KENJI (JP)
YAMANAKA TAKASHI (JP)
ASADA MAKOTO (JP)
Application Number:
PCT/JP1995/002231
Publication Date:
May 09, 1996
Filing Date:
October 31, 1995
Export Citation:
Assignee:
EISAI CO LTD (JP)
HIBI SHIGEKI (JP)
KIKUCHI KOUICHI (JP)
YOSHIMURA HIROYUKI (JP)
NAGAI MITSUO (JP)
TAGAMI KATSUYA (JP)
ABE SHINYA (JP)
HISHINUMA IEHARU (JP)
NAGAKAWA JUNICHI (JP)
MIYAMOTO NORIMASA (JP)
HIDA TAKAYUKI (JP)
OGASAWARA AICHI (JP)
HIGASHI SEIKO (JP)
TAI KENJI (JP)
YAMANAKA TAKASHI (JP)
ASADA MAKOTO (JP)
HIBI SHIGEKI (JP)
KIKUCHI KOUICHI (JP)
YOSHIMURA HIROYUKI (JP)
NAGAI MITSUO (JP)
TAGAMI KATSUYA (JP)
ABE SHINYA (JP)
HISHINUMA IEHARU (JP)
NAGAKAWA JUNICHI (JP)
MIYAMOTO NORIMASA (JP)
HIDA TAKAYUKI (JP)
OGASAWARA AICHI (JP)
HIGASHI SEIKO (JP)
TAI KENJI (JP)
YAMANAKA TAKASHI (JP)
ASADA MAKOTO (JP)
International Classes:
A61P19/02; C07C57/03; C07C229/44; C07D209/08; C07D213/69; C07D215/12; C07D215/14; C07D215/18; C07D223/16; C07D225/06; C07D231/12; C07D241/38; C07D241/42; C07D241/46; C07D261/18; C07D263/32; C07D265/36; C07D333/76; C07D405/14; C07D455/04; C07D487/04; C07D495/04; G06F17/30; (IPC1-7): C07C53/00; C07C229/00; C07D209/08; C07D215/14; C07D223/16; C07D265/36; C07D471/06; C07D487/04; C07D495/04; C07D521/00
Domestic Patent References:
| WO1995018130A1 | 1995-07-06 |
Foreign References:
| JPH069616A | 1994-01-18 | |||
| US4977276A | 1990-12-11 | |||
| JPH02268181A | 1990-11-01 | |||
| JPH0578315A | 1993-03-30 | |||
| US4894386A | 1990-01-16 | |||
| JPH01316363A | 1989-12-21 |
Other References:
HETEROCYCLES, 26(1), (1987), STOKKER GERALD E., pages 157-162.
RECL. TRAV. CHIM. PAYS-BAS, 92(5), (1973), DE KONING H., pages 683-688.
J. CHEM. SOC., PERKIN TRANS, 1(13), (1973), BADAR YASMEEN, pages 1416-1424.
MOL. CELL. BIOL., 14(1), (1994), KEIDEL SIEGFRIED, pages 287-298.
J. AM. CHEM. SOC., 115(16), (1993), CAI GUOLIN, pages 1792-1798.
TETRAHEDRON, 46(2), (1990), ROBINSON CHARLES N., pages 335-340.
COLLECT. CZECH. CHEM. COMMUN., 43(6), (1978), SILHANKOVA ALEXANDRA, pages 1484-1487.
SYNTHESIS, (12), (1987), MAKOSZA M., pages 1142-1144.
MOL. IMMUNOL., 28(6), (1991), VARGA JANOS M., pages 641-654.
J. PHARM. SCI., 82(2), (1993), SUNTHANKAR P.S., pages 543-545.
"KHIM. PRIR. SOEDIN, (1), (1978), LIVSHITS N.D., pages 63-70.", KHIMIYA PRIRODNYKH SOEDINENII, O'ZBEKISTON RESPUBLIKASI FANLAR AKADEMIYASI, UZ, no. 01, 1 January 1978 (1978-01-01), UZ, pages 63 - 70, XP008054764, ISSN: 0023-1150
BIOORG. MED. CHEM. LETT., 1(2), (1991), YU MELVIN J., pages 107-110.
RENARD P., ET AL.: "PRODUITS DE TRANSFORMATION DE LA FORMYL-6 METHYL-3 BENZOXAZOLINONE.", BULLETIN DE LA SOCIETE DE PHARMACIE DE LILLE., LILLE., FR, vol. 35., no. 02/03., 1 January 1979 (1979-01-01), FR, pages 125 - 138., XP000671535, ISSN: 0366-3507
DOPOV. AKAD. NAUK UKR. RSR. SER. B, 32(9), (1970), KHRISTEIANSEN M.G., pages 829-834.
IZV. TIMIRYAZEVSK. S-KH. AKAD., (3), (1988), GRYAZNOV A.P., pages 185-190.
HETEROCYCLES, 27(2), (1988), SAKAKIBARA JINSAKU, pages 423-435.
KHIM. GETEROTSIKL. SOEDIN, (5), (1983), DOLIDZE S.V., pages 608-612.
See also references of EP 0790228A4
RECL. TRAV. CHIM. PAYS-BAS, 92(5), (1973), DE KONING H., pages 683-688.
J. CHEM. SOC., PERKIN TRANS, 1(13), (1973), BADAR YASMEEN, pages 1416-1424.
MOL. CELL. BIOL., 14(1), (1994), KEIDEL SIEGFRIED, pages 287-298.
J. AM. CHEM. SOC., 115(16), (1993), CAI GUOLIN, pages 1792-1798.
TETRAHEDRON, 46(2), (1990), ROBINSON CHARLES N., pages 335-340.
COLLECT. CZECH. CHEM. COMMUN., 43(6), (1978), SILHANKOVA ALEXANDRA, pages 1484-1487.
SYNTHESIS, (12), (1987), MAKOSZA M., pages 1142-1144.
MOL. IMMUNOL., 28(6), (1991), VARGA JANOS M., pages 641-654.
J. PHARM. SCI., 82(2), (1993), SUNTHANKAR P.S., pages 543-545.
"KHIM. PRIR. SOEDIN, (1), (1978), LIVSHITS N.D., pages 63-70.", KHIMIYA PRIRODNYKH SOEDINENII, O'ZBEKISTON RESPUBLIKASI FANLAR AKADEMIYASI, UZ, no. 01, 1 January 1978 (1978-01-01), UZ, pages 63 - 70, XP008054764, ISSN: 0023-1150
BIOORG. MED. CHEM. LETT., 1(2), (1991), YU MELVIN J., pages 107-110.
RENARD P., ET AL.: "PRODUITS DE TRANSFORMATION DE LA FORMYL-6 METHYL-3 BENZOXAZOLINONE.", BULLETIN DE LA SOCIETE DE PHARMACIE DE LILLE., LILLE., FR, vol. 35., no. 02/03., 1 January 1979 (1979-01-01), FR, pages 125 - 138., XP000671535, ISSN: 0366-3507
DOPOV. AKAD. NAUK UKR. RSR. SER. B, 32(9), (1970), KHRISTEIANSEN M.G., pages 829-834.
IZV. TIMIRYAZEVSK. S-KH. AKAD., (3), (1988), GRYAZNOV A.P., pages 185-190.
HETEROCYCLES, 27(2), (1988), SAKAKIBARA JINSAKU, pages 423-435.
KHIM. GETEROTSIKL. SOEDIN, (5), (1983), DOLIDZE S.V., pages 608-612.
See also references of EP 0790228A4
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